Developmental toxicity of 2-ethylhexyl stearate
| Autor: | W. Pittermann, W. Aulmann, M. Potokar, Friedhelm Dr Bartnik, W. Kästner, W. Sterzel |
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| Rok vydání: | 2000 |
| Předmět: |
animal structures
Developmental toxicity Physiology Toxicology Rats Sprague-Dawley chemistry.chemical_compound Pregnancy Stearate Animals Ethylhexyl stearate Caproates Fetal Death Dose-Response Relationship Drug Abnormalities Drug-Induced General Medicine Teratology Rats Dose–response relationship Teratogens chemistry Prenatal Exposure Delayed Effects embryonic structures Toxicity Gestation Female Stearic Acids Maternal toxicity Food Science |
| Zdroj: | Food and Chemical Toxicology. 38:57-63 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/s0278-6915(99)00124-6 |
| Popis: | 2-Ethylhexyl stearate was investigated in an embryo-/foetotoxicity and teratogenicity study on rats according to OECD guidelines for the testing of chemicals (No. 414). Dose levels of 0 (arachidis oil), 100, 300 and 1000mg/kg body weight/day were administered by gavage. Dams tolerated the applied dose levels without any toxic effects. Pre- and post-implantation loss and mean numbers of resorptions were unaffected by treatment. All parameters were comparable with the animals of the control group. Skeletal and visceral investigations revealed no treatment-related malformations. For embryo-/foetotoxicity, teratogenicity and maternal toxicity a NOAEL of 1000mg/kg was deduced. |
| Databáze: | OpenAIRE |
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