| Autor: |
Silvia G. Inderbinen, Manuel Kley, Michael Zogg, Manuel Sellner, André Fischer, Jacek Kędzierski, Stéphanie Boudon, Anton M. Jetten, Martin Smieško, Alex Odermatt |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Toxicology. 471 |
| ISSN: |
1879-3185 |
| Popis: |
Retinoic acid-related orphan receptor γt (RORγt) regulates immune responses and its impaired function contributes to inflammatory and autoimmune diseases and may promote skin cancer. Synthetic inverse RORγt agonists block the production of Th17-associated cytokines including interleukin (IL)-17A and IL-22 and are under investigation for treatment of such pathologies. Unintentional RORγt activation in skin, following exposure to environmental chemicals, may promote inflammatory skin disease. Parabens and UV-filters, frequently used as additives in cosmetics and body care products, are intensively inspected for endocrine disrupting properties. This study assessed whether such compounds can interfere with RORγ activity using a previously established tetracycline-inducible reporter gene assay in CHO cells. These transactivation experiments revealed hexylparaben, benzylparaben and benzophenone-10 as RORγ agonists (EC |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect