Impairment of Endothelium-Dependent Vasodilation of Resistance Vessels in Patients With Obstructive Sleep Apnea
| Autor: | Masahiko Kato, Virend K. Somers, William G. Haynes, Philip Roberts-Thomson, Valentina Accurso, Bradley G. Phillips, Mikolaj Winnicki |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Brachial Artery Endothelium Polysomnography Vasodilator Agents Hemodynamics Hyperemia Vasodilation Electrocardiography Heart Rate Physiology (medical) Internal medicine Humans Infusions Intra-Arterial Medicine Obesity Reactive hyperemia Ultrasonography Sleep Apnea Obstructive Dose-Response Relationship Drug business.industry Middle Aged medicine.disease Acetylcholine Obstructive sleep apnea Forearm medicine.anatomical_structure Endocrinology Blood pressure cardiovascular system Cardiology Vascular resistance Verapamil Vascular Resistance Endothelium Vascular Cardiology and Cardiovascular Medicine business Blood Flow Velocity medicine.drug |
| Zdroj: | Circulation. 102:2607-2610 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/01.cir.102.21.2607 |
| Popis: | Background —Patients with obstructive sleep apnea (OSA) experience repetitive episodic hypoxemia with consequent sympathetic activation and marked blood pressure surges, each of which may impair endothelial function. We tested the hypothesis that patients with OSA have impaired endothelium-dependent vasodilation, even in the absence of overt cardiovascular disease. Methods and Results —We studied 8 patients with OSA (age 44±4 years) and 9 obese control subjects (age 48±3 years). Patients with OSA were newly diagnosed, never treated for OSA, on no medications, and free of any other known diseases. All obese control subjects underwent complete overnight polysomnographic studies to exclude occult OSA. Resistance-vessel function was tested by use of forearm blood flow responses to intra-arterial infusions of acetylcholine (a vasodilator that stimulates endothelial release of nitric oxide), sodium nitroprusside (an exogenous nitric oxide donor), and verapamil (a calcium channel blocker). Conduit-vessel function was also evaluated by ultrasonography. Brachial artery diameter was measured under baseline conditions, during reactive hyperemia (with flow increase causing endothelium-dependent dilatation), and after sublingual administration of nitroglycerin (an endothelium-independent vasodilator). Patients with OSA had a blunted vasodilation in response to acetylcholine ( P Conclusions —Patients with OSA have an impairment of resistance-vessel endothelium-dependent vasodilation. This may be implicated in the pathogenesis of hypertension and heart failure in this condition. |
| Databáze: | OpenAIRE |
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