Meta-analysis indicating that high ALCAM expression predicts poor prognosis in colorectal cancer
| Autor: | Chunmei Qian, Lin Jing, Yeqing Zhang, Jianlin Ren, Yu Guan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Fetal Proteins medicine.medical_specialty Poor prognosis clinical features Colorectal cancer Cell Adhesion Molecules Neuronal Gene Expression Traditional Chinese medicine Cochrane Library 03 medical and health sciences 0302 clinical medicine Antigens CD Internal medicine Tumor stage Biomarkers Tumor Medicine Humans China ALCAM Neoplasm Staging Proportional Hazards Models Traditional medicine business.industry medicine.disease Prognosis CRC 030104 developmental biology 030220 oncology & carcinogenesis Meta-analysis outcome Neoplasm Grading business Colorectal Neoplasms Publication Bias Meta-Analysis |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Yeqing Zhang 1, * , Chunmei Qian 2, * , Lin Jing 3 , Jianlin Ren 3 and Yu Guan 2 1 Department of Chinese Internal Medicine, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China 2 Department of Central Laboratory Medicine, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China 3 Department of Oncology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China * These authors contributed equally to this work Correspondence to: Yu Guan, email: newera2017@163.com Jianlin Ren, email: renjanlin666@126.com Keywords: ALCAM, outcome, clinical features, CRC Received: November 30, 2016 Accepted: April 24, 2017 Published: May 08, 2017 ABSTRACT Activated leukocyte cell adhesion molecule (ALCAM) has been linked to the development and progress of colorectal cancer (CRC). In this meta-analysis, we examined whether ALCAM expression is predictive of survival outcomes in CRC patients. We included 7 studies with 2048 patients in our meta-analysis after searching the PubMed, Cochrane Library, EMBASE, OVID and Web of Science databases. High ALCAM expression was associated with poor overall survival among CRC patients (HR = 1.94, 95%CI = 1.05–3.58, P = 0.03). High ALCAM expression was also associated with aggressive clinicopathological features such as tumor stage (T3,T4/T1,T2; HR = 2.66, 95%CI = 2.01–3.51, P 60/< 60, HR = 1.29, 95%CI = 1.01–1.66, P = 0.05). These findings indicate that high ALCAM expression is associated with poor prognosis and advanced clinicopathological characteristics in CRC patients. |
| Databáze: | OpenAIRE |
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