The design of a Social Cost-Benefit Analysis of preventive interventions for toxoplasmosis: An example of the One Health approach
| Autor: | G.A. de Wit, Talitha L Feenstra, L. M. Kortbeek, J. W. B. van der Giessen, A. A. Bonačić Marinović, Marie-Josée J. Mangen, A W M Suijkerbuijk, P F van Gils, Marieke Opsteegh |
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| Přispěvatelé: | Methods in Medicines evaluation & Outcomes research (M2O), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Value, Affordability and Sustainability (VALUE) |
| Rok vydání: | 2017 |
| Předmět: |
Protozoan Vaccines
0301 basic medicine Veterinary medicine ZOONOSES SURVEILLANCE Swine Epidemiology Cost-Benefit Analysis NETHERLANDS Biosecurity Psychological intervention Cat Diseases freezing meat 0302 clinical medicine Cost of Illness Food Parasitology prevention Freezing Medicine Animal Husbandry ONE HEALTH CONTEXT Swine Diseases Cost–benefit analysis risk assessment DISEASE BURDEN Infectious Diseases One Health cat vaccination Risk assessment toxoplasmosis Meat 030231 tropical medicine 030106 microbiology GONDII OOCYSTS 03 medical and health sciences Environmental health Journal Article Animals Humans QUALITY INFECTIVITY Disease burden General Veterinary General Immunology and Microbiology business.industry Social cost FOODBORNE PATHOGENS Public Health Environmental and Occupational Health FRAMEWORK medicine.disease Toxoplasmosis MICE Toxoplasmosis Animal Food Storage Socioeconomic Factors Cats business social cost-benefit analysis |
| Zdroj: | Zoonoses and Public Health, 65(1), 185. Wiley-Blackwell Zoonoses and Public Health, 65(1), 185-194. Wiley |
| ISSN: | 1863-1959 |
| DOI: | 10.1111/zph.12417 |
| Popis: | Toxoplasma gondii infections cause a large disease burden in the Netherlands, with an estimated health loss of 1,900 Disability Adjusted Life Years and a cost-of-illness estimated at Euro44 million annually. Infections in humans occur via exposure to oocysts in the environment and after eating undercooked meat containing tissue cysts, leading to asymptomatic or mild symptoms, but potentially leading to the development of ocular toxoplasmosis. Infection in pregnant women can lead to stillbirth and disorders in newborns. At present, prevention is only targeted at pregnant women. Cat vaccination, freezing of meat destined for undercooked consumption and enhancing biosecurity in pig husbandries are possible interventions to prevent toxoplasmosis. As these interventions bear costs for sectors in society that differ from those profiting from the benefits, we perform a social cost-benefit analysis (SCBA). In an SCBA, costs and benefits of societal domains affected by the interventions are identified, making explicit which stakeholder pays and who benefits. Using an epidemiological model, we consider transmission of T.gondii after vaccination of all owned cats or cats at livestock farms. To identify relevant high-risk meat products that will be eaten undercooked, a quantitative microbial risk assessment model developed to attribute predicted T.gondii infections to specific meat products will be used. In addition, we evaluate serological monitoring of pigs at slaughter followed by an audit and tailor made advice for farmers in case positive results were found. The benefits will be modelled stochastically as reduction in DALYs and monetized in Euro's following reference prices for DALYs. If the balance of total costs and benefits is positive, this will lend support to implementation of these preventive interventions at the societal level. Ultimately, the SCBA will provide guidance to policy makers on the most optimal intervention measures to reduce the disease burden of T.gondii in the Netherlands. |
| Databáze: | OpenAIRE |
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