Rational Design of a Multipurpose Bioadhesive Vaginal Film for Co-Delivery of Dapivirine and Levonorgestrel
| Autor: | Vinayak Sant, Sheila Grab, Yvonne T. Cosgrove Sweeney, Philip Graebing, Sravan Kumar Patel, Galit Regev, Dorothy L. Patton, Lin Wang, Lisa C. Rohan, Jing Li |
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| Rok vydání: | 2019 |
| Předmět: |
dapivirine
Bioadhesive Dapivirine Pharmaceutical Science 02 engineering and technology Pharmacology 030226 pharmacology & pharmacy Article Dosage form 03 medical and health sciences 0302 clinical medicine Pharmacokinetics In vivo medicine Levonorgestrel multipurpose prevention technologies levonorgestrel business.industry HIV 021001 nanoscience & nanotechnology 3. Good health contraception Drug delivery bioadhesive vaginal film 0210 nano-technology business Unintended pregnancy unintended pregnancy medicine.drug |
| Zdroj: | Pharmaceutics Volume 12 Issue 1 |
| ISSN: | 1999-4923 |
| DOI: | 10.3390/pharmaceutics12010001 |
| Popis: | Human immunodeficiency virus (HIV) infection and unintended pregnancy, which can lead to life-threatening complications, are two major burdens for female reproductive health. To address these pressing health issues, multipurpose prevention technologies (MPTs) are proposed to deliver two or more drugs simultaneously. MPTs could offer several benefits for users such as improved convenience, increased effectiveness, reduced cost, and decreased environmental burden. Here, we report the development, and in vitro and in vivo assessment of a bioadhesive vaginal film as a coitally-independent MPT dosage form for delivering dapivirine (DPV) and levonorgestrel (LNG) to prevent HIV infection and unintended pregnancy, respectively. After confirming the feasibility of bioadhesive film use for weekly drug delivery in vivo through colpophotography and MRI evaluation, the pharmacokinetics (PK) of DPV/LNG single entity and combination bioadhesive films was investigated in pigtailed macaques (n = 5). Both drugs from single entity or combination films were able to provide sustained drug release in vivo. The combination film showed lower local tissue clearance for DPV and exhibited significantly increased plasma concentration for LNG as compared to the single entity film. This proof-of-concept study demonstrates the ability of this novel bioadhesive film platform to deliver LNG and DPV simultaneously as an MPT product for the prevention of HIV infection and unintended pregnancy. |
| Databáze: | OpenAIRE |
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