Selective Synthesis of ortho-Substituted Diarylsulfones by Using NHC-Au Catalysts under Mild Conditions

Autor:	Zhang-Gao Le, Tao Tu, Haibo Zhu, Daheng Wen, Yajing Shen
Rok vydání:	2019
Předmět:	inorganic chemicals Steric effects Potassium metabisulfite 010405 organic chemistry Aryl Organic Chemistry 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Physical and Theoretical Chemistry
Zdroj:	Organic Letters. 21:974-979
ISSN:	1523-7052 1523-7060
Popis:	A single-step gold(I)-catalyzed chemoselective protocol to access ortho-substituted diarylsulfones has been established. Acenaphthoimidazolylidene gold complexes are effective catalysts for the arylsulfonylation of boronic acids by potassium metabisulfite (K2S2O5) and diaryliodonium salts to access (poly-)ortho-substituted diarylsulfones even in gram scale. Unlike the transition metal-catalyzed two-component coupling systems, the sterically hindered aryl groups in diaryliodonium salts are preferentially transferred over less bulky ones to form synthetically difficult targets, including those of pharmaceutical importance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8920bed50195666f622c8e1b21ff5334 https://doi.org/10.1021/acs.orglett.8b03957 Zobrazit plný text záznamu