Fhit expression in human gastric adenomas and intramucosal carcinomas: correlation with Mlh1 expression and gastric phenotype
| Autor: | Akihide Hosoda, Shiota G, Koichiro Kawaguchi, Y. Murawaki, Hironobu Andachi, Atsushi Tsutsumi, Masahiko Koda, Kazuo Yashima, Shuji Kitaoka, Yukihiro Kishimoto, Hisao Ito |
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| Rok vydání: | 2004 |
| Předmět: |
Adenoma
Male Cancer Research Pathology medicine.medical_specialty mucin phenotype DNA Repair Base Pair Mismatch Biology MLH1 Intestinal mucosa Stomach Neoplasms FHIT endoscopic mucosal resection medicine Carcinoma Humans Genes Tumor Suppressor Intestinal Mucosa Stomach cancer neoplasms Adaptor Proteins Signal Transducing Aged gastric cancer Fhit Chromosomal fragile site Molecular and Cellular Pathology Mlh1 Nuclear Proteins Middle Aged medicine.disease Immunohistochemistry digestive system diseases Acid Anhydride Hydrolases Neoplasm Proteins Cell Transformation Neoplastic Phenotype Oncology Female Carrier Proteins MutL Protein Homolog 1 |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/sj.bjc.6601601 |
| Popis: | The fragile histidine triad (FHIT) gene, encompassing the FRA3B fragile site at chromosome 3p14.2, is a candidate tumour suppressor gene involved in a variety of tumours, including gastric carcinomas. Recently, it has been reported that the FHIT gene may be a target of damage in some of mismatch-deficient tumours. To clarify further the role of the Fhit protein in gastric carcinogenesis, we investigated whether Fhit expression in early gastric neoplasia is associated with mismatch repair protein expression and cellular phenotype. Fhit, Mlh1 and phenotypic expression were evaluated immunohistochemically in 87 early gastric neoplasias, comprising 32 adenomas and 55 intramucosal carcinomas, resected by endoscopic mucosal resection therapy. Significant loss or reduction of Fhit expression was noted in four (12.5%) of the 32 adenomas and 21 (38.2%) of the 55 intramucosal carcinomas. The rate of abnormal Fhit expression was significantly higher in intramucosal carcinomas than in adenomas (P=0.021). Moreover, reduced Fhit expression was found to be significantly associated with loss of Mlh1 expression in early gastric neoplasia (P=0.0011). Furthermore, we also detected a significant association between reduced Fhit expression and gastric phenotype (P=0.0018). These results suggested that reduced Fhit expression occurs in the early stage of gastric carcinogenesis and could be correlated with a lack of Mlh1 expression and gastric phenotype. |
| Databáze: | OpenAIRE |
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