Treatment of Early Clinically Staged Hodgkin's Disease with a Combination of ABVD Chemotherapy Plus Limited Field Radiotherapy
| Autor: | E. Grigoriou, Nikolaos Harhalakis, John Apostolidis, Themistokles Karmiris, E. Spanou, J. Baltadakis, Chrisanthi H. Mitsouli, Dimitri Karakasis, Maria Bakiri, M. Tsantekidou, H. Mihalakeas, Maria Pagoni, Emmanuel Nikiforakis |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Cancer Research Adolescent Dacarbazine medicine.medical_treatment Vinblastine Bleomycin Disease-Free Survival chemistry.chemical_compound Antineoplastic Combined Chemotherapy Protocols medicine Humans Combined Modality Therapy Stage (cooking) Aged Neoplasm Staging Retrospective Studies Chemotherapy business.industry Remission Induction Radiotherapy Dosage Hematology Middle Aged Hodgkin Disease Surgery Radiation therapy Treatment Outcome chemistry ABVD Oncology Doxorubicin Female business medicine.drug |
| Zdroj: | Leukemia & Lymphoma. 44:1523-1528 |
| ISSN: | 1042-8194 |
| DOI: | 10.1080/1042819031000099689 |
| Popis: | The current management of early stage Hodgkin's disease (HD) is usually based on clinical staging, combined modality therapy and the use of less toxic chemotherapy regimens. This approach entails high cure rates, while ensures less long term toxicity with avoidance of laparotomy. The aim of this study was to assess the efficacy of a brief course of Adriamycin, Bleomycin, Vinblastine, Dacarbazine (ABVD) chemotherapy followed by limited field radiotherapy (RT) in favorable clinical stage (CS) I and IIA HD. Forty patients, aged 17-68 (median 34) years, with favorable CS I and IIA HD, without bulky mediastinal disease, have been treated with 4-6 (median 4) cycles of ABVD plus limited field RT. Twenty seven (67%) patients received 4 cycles of chemotherapy, while 13 received 5-6 cycles. Thirty five (87%) patients received limited field RT with dose 24-36 Gy and five (13%) received extended field with 36-46 Gy. All patients responded completely to chemotherapy. One patient experienced a relapse two months after the end of therapy. All patients are alive; 39 in continuous complete remission. With a median follow-up period of 44 months (range 18-101) the actuarial overall and progress free survival was 100 and 97% at 5 years. We did not observe any case of secondary leukemia or solid tumor. Pulmonary toxicity was mild in cases of mediastinal irradiation. Considering the short follow-up time and the small number of patients, the combination of a brief course of ABVD plus regional RT is a very efficacious treatment of favorable CS I and IIA HD with mild toxicity. However, long term survival data are needed, which could give confident answers regarding the risk of late therapy related complications, particularly second malignancies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|