Increased risk of multiple sclerosis after late Epstein-Barr virus infection: a historical prospective study
| Autor: | Anné Møller-Larsen, Hans Kerzel Andersen, Sven Haahr, L. S. Eriksen, Nils Koch-Henriksen |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics Multiple Sclerosis Mononucleosis Adolescent Denmark Immunology Antibodies Heterophile Disease medicine.disease_cause Danish 03 medical and health sciences 0302 clinical medicine Sex Factors Risk Factors Epidemiology medicine Prevalence Immunology and Allergy Animals Humans 030212 general & internal medicine Infectious Mononucleosis Prospective Studies Registries Risk factor Age of Onset Prospective cohort study Epstein–Barr virus infection business.industry Multiple sclerosis Age Factors General Medicine Middle Aged medicine.disease Epstein–Barr virus language.human_language Neurology language Female Viral disease Neurology (clinical) Age of onset business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Multiple sclerosis (Houndmills, Basingstoke, England). 1(2) |
| ISSN: | 1352-4585 |
| Popis: | An association between infectious mononucleosis (IM) and MS has been proposed. In a historical prospective study we used records from the Danish State Serum Institute on heterophils antibody (HA) tests for IM performed in all Danish patients over a number of years. Included in the analysis were 6853 HA-positive persons analyzed from 1968 to 1978 (except 1975) and 12 886 HA-negative per sons analyzed in the years 1968, 1969, 1970 and 1978. A search for these persons in the central nationwide Danish Multiple Sclerosis Registry (DMSR) was performed. Among the HA-positive persons 16 cases of MS which met the diagnostic criteria were found with onset of MS after the year of the HA test and before follow-up on 1 January 1991. The expected number for a Danish population, matched by sex, age and year at start of observation, was 5.70 (P 0.05). Although Epstein-Barr virus is not suggested in itself to be the cause of MS, we propose that it is a co-factor in the pathogenesis of this disease. |
| Databáze: | OpenAIRE |
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