GABA and glutamate receptors are involved in modulating pacemaker activity in hydra
| Autor: | G Kass-Simon, P Pierobon, A Pannaccione |
|---|---|
| Přispěvatelé: | KASS SIMON, G, Pannaccione, Anna, Pierobon, P. |
| Rok vydání: | 2003 |
| Předmět: |
Agonist
medicine.medical_specialty Physiology medicine.drug_class Hydra Glutamic Acid glutamate Kainate receptor AMPA receptor Biology Biochemistry GABA Antagonists GABA chemistry.chemical_compound Receptors GABA Biological Clocks Internal medicine Culture Techniques Quinoxalines medicine Excitatory Amino Acid Agonists Animals GABA-A Receptor Agonists GABA-A Receptor Antagonists Molecular Biology GABA Agonists alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid gamma-Aminobutyric Acid Kainic Acid Glutamate receptor LGIC Bicuculline GABA receptor antagonist Endocrinology nervous system chemistry Receptors Glutamate pacemaker systems embryonic structures NBQX Excitatory Amino Acid Antagonists medicine.drug Ionotropic effect |
| Zdroj: | 136 (2003): 329–342. info:cnr-pdr/source/autori:Kass-Simon G.1, Pannaccione A.2, Pierobon P.3/titolo:GABA and glutamate receptors are involved in modulating pacemaker activity in hydra/doi:/rivista:/anno:2003/pagina_da:329/pagina_a:342/intervallo_pagine:329–342/volume:136 |
| ISSN: | 1095-6433 |
| Popis: | The effects of gamma-amino butyric acid (GABA) and glutamate, their ionotropic agonists and antagonists on hydra’s ectodermal and endodermal pacemaker systems were studied. GABA decreased ectodermal body contraction bursts (CBs) and the number of pulses in a burst (PyCB) and endodermal rhythmic potentials (RPs); tentacle pulses (TPs) were not affected. The GABA agonist, muscimol, and the benzodiazepine receptor agonist, diazepam, mimicked the A effects of GABA on the endodermal system. The GABA antagonist bicuculline counteracted GABA’s effects. Low A concentrations of glutamate increased CBs and RPs. Higher concentrations required concanavalin A (Con A) to produce the same effect on CBs and PyCB. TPs were increased by high concentrations of glutamate and kainate. The ionotropic glutamate agonist, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) also required Con A to increase CBs and RPs. The effects of AMPA were antagonized by 6-nitro-7-sulfamoylbenzowfxquinoxaline-2,3-dione (NBQX), which, per se, decreased CBs. The results indicate that GABA and glutamate, acting on their ionotropic receptors, modify the impulses of hydra’s pacemaker systems. On the whole GABA decreased the outputs of both ectodermal and endodermal impulse generating systems, while glutamate increased them. 2003 Elsevier Science Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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