c-erbB3 protein expression in ovarian cancer
| Autor: | C M Hughes, Thangarajan Rajkumar, W J Gullick, G W H Stamp |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
chemistry.chemical_classification
Pathology medicine.medical_specialty business.industry medicine.drug_class Peptide Monoclonal antibody medicine.disease Epithelium Pathology and Forensic Medicine medicine.anatomical_structure Growth factor receptor chemistry Cytoplasm Papers Cancer research Medicine ERBB3 Stage (cooking) business Ovarian cancer |
| Zdroj: | Molecular Pathology. 49:M199-M202 |
| ISSN: | 1366-8714 |
| DOI: | 10.1136/mp.49.4.m199 |
| Popis: | Aims—To study the prevalence of overexpression of c-erbB3 growth factor receptor in ovarian carcinomas and to analyse its relation to histological subtype, stage and grade of the tumours. Methods—Ninety eight ovarian carcinomas were evaluated immunohistochemically using the RTJ1 monoclonal antibody raised against a synthetic peptide, the sequence of which was derived from the cytoplasmic domain of the c-erbB3 protein. Results—Of the tumours, 16% (16/98) overexpressed c-erbB3 protein relative to normal ovarian epithelium, whereas 22% (22/98) were completely negative. There was a statistically significant association between overexpression and well differentiated grade. Conclusions—These findings suggest that c-erbB3 protein overexpression occurs in a significant proportion of ovarian cancers and is correlated with differentiation. Overexpression may merit further investigation as a potential prognostic indicator and as a target for new treatment. |
| Databáze: | OpenAIRE |
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