Neurosonological Findings Related to Non-Motor Features of Parkinson’s Disease: A Systematic Review
| Autor: | Patricia Martínez-Sánchez, Javier Fernández Pérez, Antonio Arjona Padillo, Manuel Payán Ortiz, Laura Amaya Pascasio, María Victoria Mejías Olmedo, Cristina Del Toro Pérez, Jesús Olivares Romero |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Psychosis
Pediatrics medicine.medical_specialty Parkinson's disease transcranial sonography autonomic dysfunction bladder dysfunction Neurosciences. Biological psychiatry. Neuropsychiatry apathy 03 medical and health sciences 0302 clinical medicine systematic review medicine Dementia Apathy Restless legs syndrome Depression (differential diagnoses) 030304 developmental biology 0303 health sciences business.industry General Neuroscience medicine.disease non-motor symptoms Transcranial Doppler Overactive bladder depression Parkinson’s disease restless legs syndrome cognitive disorders sleep disorders hallucinations medicine.symptom business 030217 neurology & neurosurgery RC321-571 dementia |
| Zdroj: | Brain Sciences riUAL. Repositorio Institucional de la Universidad de Almería Universidad de Almería Brain Sciences, Vol 11, Iss 776, p 776 (2021) |
| ISSN: | 2076-3425 |
| Popis: | Non-motor symptoms (NMS) in Parkinson’s disease (PD), including neuropsychiatric or dysautonomic complaints, fatigue, or pain, are frequent and have a high impact on the patient’s quality of life. They are often poorly recognized and inadequately treated. In the recent years, the growing awareness of NMS has favored the development of techniques that complement the clinician’s diagnosis. This review provides an overview of the most important ultrasonographic findings related to the presence of various NMS. Literature research was conducted in PubMed, Scopus, and Web of Science from inception until January 2021, retrieving 23 prospective observational studies evaluating transcranial and cervical ultrasound in depression, dementia, dysautonomic symptoms, psychosis, and restless leg syndrome. Overall, the eligible articles showed good or fair quality according to the QUADAS-2 assessment. Brainstem raphe hypoechogenicity was related to the presence of depression in PD and also in depressed patients without PD, as well as to overactive bladder. Substantia nigra hyperechogenicity was frequent in patients with visual hallucinations, and larger intracranial ventricles correlated with dementia. Evaluation of the vagus nerve showed contradictory findings. The results of this systematic review demonstrated that transcranial ultrasound can be a useful complementary tool in the evaluation of NMS in PD. |
| Databáze: | OpenAIRE |
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