Gut permeability and cognitive decline: A pilot investigation in the Northern Manhattan Study
| Autor: | Sabita Roy, Ralph L. Sacco, Clinton B. Wright, Yuen K. Cheung, Bonnie E. Levin, Tanja Rundek, M.S.V. Elkind, Janet T. DeRosa, Mady Hornig, V. A. Del Brutto, Hannah Gardener |
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| Rok vydání: | 2021 |
| Předmět: |
education.field_of_study
biology business.industry CD14 Population Neuropsychology Physiology Neurosciences. Biological psychiatry. Neuropsychiatry Cognition Gut flora biology.organism_classification medicine.disease Article General Earth and Planetary Sciences Medicine Effects of sleep deprivation on cognitive performance Cognitive decline business education Stroke RC321-571 General Environmental Science |
| Zdroj: | Brain, Behavior, & Immunity-Health, Vol 12, Iss, Pp 100214-(2021) Brain, behavior, & immunity-health |
| ISSN: | 2666-3546 |
| DOI: | 10.1016/j.bbih.2021.100214 |
| Popis: | BackgroundGut microbiota may impact cognitive function and decline, though data is limited. This pilot study examines the associations between gut dysbiosis products, plasma lipopolysaccharide (LPS) and soluble CD14 (sCD14), with cognitive decline and immune molecule activation among 40 participants in the longitudinal population-based Northern Manhattan Study.MethodsWe selected stroke- and dementia-free participants at baseline with high activation levels of core components of the immune signaling pathways underlying microbiota metabolite-cognitive associations (IL-1, IL-17, TNF). Participants were followed with up to three complete neuropsychological assessments.ResultsElevated sCD14 was associated with high levels of IL-1 (pConclusionsThese preliminary data support the hypothesis that gut dysbiosis leads to systemic and neuro-inflammation, and subsequently cognitive decline. Further large targeted and untargeted gut microbiota-derived metabolomic studies are needed. |
| Databáze: | OpenAIRE |
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