Consistency of the Glycation Gap with the Hemoglobin Glycation Index Derived from a Continuous Glucose Monitoring System
| Autor: | Ki-Ho Song, Han Na Joung, Ki-Hyun Baek, Mee Kyoung Kim, Hyuk-Sang Kwon |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty glycosylation endocrine system diseases Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism glycosylated hemoglobin a Type 2 diabetes lcsh:Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Glycated albumin Glycation Diabetes management Internal medicine medicine Humans glycosylated serum albumin Glycemic Glycated Hemoglobin lcsh:RC648-665 Continuous glucose monitoring Blood Glucose Self-Monitoring Middle Aged Prognosis medicine.disease Diabetes Mellitus Type 2 chemistry 030220 oncology & carcinogenesis Original Article Female Hemoglobin Glycated hemoglobin Biomarkers Follow-Up Studies |
| Zdroj: | Endocrinology and Metabolism, Vol 35, Iss 2, Pp 377-383 (2020) Endocrinology and Metabolism |
| ISSN: | 2093-5978 2093-596X |
| Popis: | Background Discordances between glycated hemoglobin (HbA1c) levels and glycemic control are common in clinical practice. We aimed to investigate the consistency of the glycation gap with the hemoglobin glycation index (HGI). Methods From 2016 to 2019, 36 patients with type 2 diabetes were enrolled. HbA1c, glycated albumin (GA), and fasting blood glucose levels were simultaneously measured and 72-hour continuous glucose monitoring (CGM) was performed on the same day. Repeated tests were performed at baseline and 1 month later, without changing patients' diabetes management. The HGI was calculated as the difference between the measured HbA1c and the predicted HbA1c that was derived from CGM. The glycation gap was calculated as the difference between the measured and GA-based predicted HbA1c levels. Results Strong correlations were found between the mean blood glucose (MBG)-based HGI and the prebreakfast glucose-based HGI (r=0.867, Pl0.001) and between the glycation gap and the MBG-based HGI (r=0.810, Pl0.001). A close correlation was found between the MBG-based HGI at baseline and that after 1 month (r=0.729, Pl0.001), with a y-intercept of 0 and a positive slope. Conclusion The HGI and glycation gap were highly reproducible, and the magnitudes of repeated determinations were closely correlated. Patients with similar mean glucose levels may have significantly different HbA1c levels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|