Regulating Bone Formation via Controlled Scaffold Degradation
| Autor: | Molly K. Smith, A. Albeiruti, Hyunjoon Kong, Eben Alsberg, David J. Mooney, Yoshiaki Hirano |
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| Rok vydání: | 2003 |
| Předmět: |
0301 basic medicine
Alginates Polymers Bone tissue Mice 03 medical and health sciences 0302 clinical medicine Tissue engineering Osteogenesis In vivo Absorbable Implants medicine Animals General Dentistry chemistry.chemical_classification Osteoblasts Tissue Engineering Chemistry Biomaterial Hydrogels 030206 dentistry Polymer Biodegradation Elasticity Rats Molecular Weight Biodegradation Environmental 030104 developmental biology medicine.anatomical_structure Gamma Rays Self-healing hydrogels Biophysics Degradation (geology) |
| Zdroj: | Journal of Dental Research. 82:903-908 |
| ISSN: | 1544-0591 0022-0345 |
| DOI: | 10.1177/154405910308201111 |
| Popis: | It is widely assumed that coupling the degradation rate of polymers used as cell transplantation carriers to the growth rate of the developing tissue will improve its quantity or quality. To test this hypothesis, we developed alginate hydrogels with a range of degradation rates by gamma-irradiating high-molecular-weight alginate to yield polymers of various molecular weights and structures. Decreasing the size of the polymer chains increased the degradation rate in vivo, as measured by implant retrieval rates, masses, and elastic moduli. Rapidly and slowly degrading alginates, covalently modified with RGD-containing peptides to control cell behavior, were then used to investigate the effect of biodegradation rate on bone tissue development in vivo. The more rapidly degrading gels led to dramatic increases in the extent and quality of bone formation. These results indicate that biomaterial degradability is a critical design criterion for achieving optimal tissue regeneration with cell transplantation. |
| Databáze: | OpenAIRE |
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