NLRP3 as a sensor of metabolism gone awry
| Autor: | Christina J Groß, Benedikt S. Saller, Olaf Groß, Oliver Gorka, Tobias Madl, Emilia Neuwirt |
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| Rok vydání: | 2021 |
| Předmět: |
Inflammation
0106 biological sciences 0303 health sciences Innate immune system integumentary system Inflammasomes Biomedical Engineering Bioengineering Inflammasome Biology 01 natural sciences Immunity Innate 03 medical and health sciences 010608 biotechnology NLR Family Pyrin Domain-Containing 3 Protein medicine Humans medicine.symptom human activities Neuroscience 030304 developmental biology Biotechnology medicine.drug |
| Zdroj: | Current Opinion in Biotechnology. 68:300-309 |
| ISSN: | 0958-1669 |
| Popis: | The NLRP3 inflammasome is an important player in innate immunity and pathogenic inflammation. Numerous studies have implicated it in sensing endogenous danger signals, yet the precise mechanisms remain unknown. Here, we review the current knowledge on the organismal and cellular metabolic triggers engaging NLRP3, and the mechanisms involved in integrating the diverse signals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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