Gestational stress and fluoxetine treatment differentially affect plasticity, methylation and serotonin levels in the PFC and hippocampus of rat dams

Autor: Jodi L. Pawluski, Mary Gemmel, Christina Dalla, Eva L. van Donkelaar, Ine Rayen, Tiffany Loftus, Nikolaos Kokras, Harry W.M. Steinbusch
Přispěvatelé: Jonchère, Laurent, Ohio University, Maastricht University [Maastricht], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), The authors report no conflict of interest. JLP was funded by a Charge de recherche position from the Fonds De La Recherche Scientifique – F.R.S.-FNRS in Belgium and is presently funded by a Brain & Behavior Foundation NARSAD Young Investigator Grant., Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Promovendi MHN, Section Psychopharmacology, RS: FPN NPPP II, RS: MHeNs - R3 - Neuroscience, Psychiatrie & Neuropsychologie
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Postpartum depression
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Hippocampus
PREFRONTAL CORTEX
Rats
Sprague-Dawley
0302 clinical medicine
Pregnancy
SSRI
Neuronal Plasticity
Depression
General Neuroscience
Brain
Antidepressive Agents
female
5-HT1A RECEPTOR
postpartum depression
Prenatal Exposure Delayed Effects
5-HT1A receptor
Antidepressant
Psychology
Selective Serotonin Reuptake Inhibitors
medicine.drug
medicine.medical_specialty
Serotonin
[SDV.SP.MED] Life Sciences [q-bio]/Pharmaceutical sciences/Medication
SEX-DIFFERENCES
Serotonin reuptake inhibitor
neuroplasticity
DEPRESSIVE-LIKE BEHAVIOR
NUCLEUS-ACCUMBENS
Methylation
neurotransmitters
CELL-PROLIFERATION
03 medical and health sciences
[SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication
Stress
Physiological
FEMALE RATS
Internal medicine
Fluoxetine
medicine
Animals
Depressive Disorder
Dentate gyrus
[SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
antidepressant medication
medicine.disease
POSTPARTUM BLUES
030104 developmental biology
Endocrinology
PRENATAL RESTRAINT STRESS
ANTENATAL MATERNAL ANXIETY
030217 neurology & neurosurgery
Postpartum period
Zdroj: Neuroscience
Neuroscience, 2016, 327, pp.32-43. ⟨10.1016/j.neuroscience.2016.03.068⟩
Neuroscience, Elsevier-International Brain Research Organization, 2016, 327, pp.32-43. ⟨10.1016/j.neuroscience.2016.03.068⟩
Neuroscience, 327, 32-43. Elsevier Science
ISSN: 0306-4522
1873-7544
Popis: Women are more likely to develop depression during childbearing years with up to 20% of women suffering from depression during pregnancy and in the postpartum period. Increased prevalence of depression during the perinatal period has resulted in frequent selective serotonin reuptake inhibitor (SSRI) antidepressant treatment; however the effects of such medications on the maternal brain remain limited. Therefore, the aim of the present study is to investigate the effects of the SSRI medication, fluoxetine, on neurobiological differences in the maternal brain. To model aspects of maternal depression, gestational stress was used. Sprague-Dawley rat dams were exposed to either gestational stress and/or fluoxetine (5mg/kg/day) to form the following four groups: 1. Control+Vehicle, 2. Stress+Vehicle, 3. Control+Fluoxetine, and 4. Stress+Fluoxetine. At weaning maternal brains were collected. Main findings show that gestational stress alone increased synaptophysin and serotonin metabolism in the cingulate cortex2 region of the cortex while fluoxetine treatment after stress normalized these effects. In the hippocampus, fluoxetine treatment, regardless of gestational stress exposure, decreased both global measures of methylation in the dentate gyrus, as measured by Dnmt3a immunoreactivity, as well as serotonin metabolism. No further changes in synaptophysin, PSD-95, or Dnmt3a immunoreactivity were seen in the cortical or hippocampal areas investigated. These findings show that gestational stress and SSRI medication affect the neurobiology of the maternal brain in a region-specific manner. This work adds to a much needed area of research aimed at understanding neurobiological changes associated with maternal depression and the role of SSRI treatment in altering these changes in the female brain.
Databáze: OpenAIRE
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