Microvilli and desmosomes of squamous cell carcinoma cells in tongue carcinoma related to regional lymph node metastasis: ultrastructural and immunohistochemical studies with transferrin receptor
| Autor: | Yutaka Kimijima, Nobuyuki Tanaka, Takao Miyamoto, Masafumi Mimura, Shizuko Ichinose |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Immunoelectron microscopy Cell Transferrin receptor Biology Metastasis Desmosome Receptors Transferrin medicine Humans Aged Aged 80 and over Microvilli Cell growth Desmosomes Middle Aged medicine.disease Immunohistochemistry Tongue Neoplasms Microscopy Electron medicine.anatomical_structure Lymphatic Metastasis Carcinoma Squamous Cell Ultrastructure Anatomy |
| Zdroj: | Medical Electron Microscopy. 33:157-164 |
| ISSN: | 1437-773X 0918-4287 |
| DOI: | 10.1007/s007950000016 |
| Popis: | Squamous cell carcinomas of the tongue (n = 49), consisting of 21 cases with cervical lymph node metastasis and 28 nonmetastatic cases, were examined by electron microscopy with special emphasis on tumor cell attach-ment. No difference of tumor size (T classification) or pathological findings between the metastatic group and the nonmetastatic group was found. The metastatic cases had numerous microvilli and a small number of desmosomes regardless of the width of the intercellular spaces. The nonmetastatic cases had few microvilli in relatively wide intercellular spaces, or, in the cases in which numerous microvilli were present in the narrow intercellular spaces, the tumor cells were connected by a large number of desmosomes. Transferrin receptor, which is a marker of cell proliferation, was localized in the cell membrane by immunohistochemistry and especially in microvilli by immunoelectron microscopy. It is suggested that microvilli might be related to the proliferation and the metastasis of squamous cell carcinoma cells. |
| Databáze: | OpenAIRE |
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