Study Of Anticancer Activity Of Brusatol, Curcumin And Paraquat Against Cancer Cell Line Through Western Blotting Study Analysis

Autor: Dilla Jose, P. Senthilkumaar
Rok vydání: 2018
Předmět:
DOI: 10.5281/zenodo.1210257
Popis: The present study scrutinized the anticancer activity of paraquat, curcumin, paraquat + curcumin; and brusatol + curcumin + paraquat against human colon adenocarcinoma cell line (Caco-2) and human pulmonary carcinoma cell line (NCI-H292). In adenocarcinoma cell line study, at the presence of curcumin, significant activation (+++) of Nuclear factor erythroid 2-related factor 2 (Nrf2) was noticed. In the combination of Brusatol + Curcumin + Paraquat, less activation (+) of Nuclear factor erythroid 2-related factor 2 (Nrf2) was observed. But in Pulmonary Carcinoma, at the combination of Brusatol + Curcumin + Paraquat, less activation (+) of Nuclear factor erythroid 2-related factor 2 (Nrf2) was observed. Commonly, in both cancer cell line, no activation (-) of Nuclear factor erythroid 2-related factor 2 (Nrf2) was seen in control. This study confirmed that the effect of anticancer of curcumin and its combinations.
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Databáze: OpenAIRE
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