Role of the Gut⁻Liver Axis in Driving Parenteral Nutrition-Associated Injury
| Autor: | William Phillips, Chandrashekhara Manithody, Amber Price, Vindhya Kakarla, Christine Denton, Julie Friend, Armando Salim Munoz Abraham, Ajay Jain, Hector Osei, Matthew Westrich, Keith Blomenkamp, Joseph Krebs |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty cholesterol 7 alpha-hydroxylase 1 parenteral nutrition Review farnesoid x receptor Gastroenterology 03 medical and health sciences Liver disease 0302 clinical medicine Internal medicine Medicine In patient Significant risk fibroblast growth factor 19 business.industry lcsh:RJ1-570 Enteral feedings lcsh:Pediatrics medicine.disease 3. Good health glucagon like peptide 030104 developmental biology Parenteral nutrition Associated injury Pediatrics Perinatology and Child Health 030211 gastroenterology & hepatology total parenteral nutrition chenodeoxycholic acid business |
| Zdroj: | Children Children, Vol 5, Iss 10, p 136 (2018) |
| ISSN: | 2227-9067 |
| Popis: | For decades, parenteral nutrition (PN) has been a successful method for intravenous delivery of nutrition and remains an essential therapy for individuals with intolerance of enteral feedings or impaired gut function. Although the benefits of PN are evident, its use does not come without a significant risk of complications. For instance, parenteral nutrition-associated liver disease (PNALD)—a well-described cholestatic liver injury—and atrophic changes in the gut have both been described in patients receiving PN. Although several mechanisms for these changes have been postulated, data have revealed that the introduction of enteral nutrition may mitigate this injury. This observation has led to the hypothesis that gut-derived signals, originating in response to the presence of luminal contents, may contribute to a decrease in damage to the liver and gut. This review seeks to present the current knowledge regarding the modulation of what is known as the “gut–liver axis” and the gut-derived signals which play a role in PN-associated injury. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|