Cognitive and linguistic outcomes after awake craniotomy in patients with high-grade gliomas

Autor: R. Trignani, R.A. Ricciuti, S. Bonifazi, V. Durazzi, Claudia Passamonti, P.P. Martorano, S. Vecchioni, Simona Lattanzi, Fabrizio Mancini
Rok vydání: 2020
Předmět:
Zdroj: Clinical Neurology and Neurosurgery. 198:106089
ISSN: 0303-8467
DOI: 10.1016/j.clineuro.2020.106089
Popis: Background Preservation of language and cognition is crucial in glioma surgery, as they are crucial aspects of daily life functioning. Several studies claimed that awake surgery in eloquent areas is demanded in low and high-grade gliomas. Cognitive and language outcome has been less investigated in high-grade gliomas compared to low-grade. Method We analyzed the neuropsychological and neuro-oncological outcome of nineteen patients (from a cohort of forty patients) who underwent fully awake surgery for resection of malignant tumors located in eloquent areas. Results Post-surgery, linguistic functions were unchanged in 80 % of patients. Slight impairments in memory and executive functions were observed in about 50 % of patients. Survival rate at one year follow-up was 89 %. Results showed that awake procedure is safe, well tolerated and related with good linguistic outcome similar to low-grade gliomas. The majority of patients reported a good outcome in term of quality of life. Conclusions Our results confirm that awake surgery is associated to good cognitive and linguistic clinical outcome also in malignant tumors.
Databáze: OpenAIRE
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