| Autor: |
Asli Yilmaz, Gabriella Nesi, Josep Lloreta, Oluwole Fadare, Athanase Billis, Jesse K. McKenney, Omar Hameed, Isabel Trias, Neriman Gokden, Bungo Furusato, Ai Ying Chuang, Anne Y. Warren, Peter W. Nichols, Puay Hoon Tan, Mahul B. Amin, Guido Martignoni, Rodolfo Montironi, Holger Moch, Ming Zhou, Daniel A. Fajardo, Cynthia Cohen, David G. Bostwick, Bhuvana Srinivasan, Semra Olgac, Stephen Rohan, Laura Irene Jufe, Katayoon Rezaei, Marina Scarpelli, Khalid Ahmed, Ruben Ronchetti, Nilesh S. Gupta, Barbara Loftus, Martin Susani, Constantina Petraki, Hikmat Al Ahmadie, Michelle S. Hirsch, Sundus Hussein, Joanna Perry-Keene, Pedram Argani, Ondrej Hes, John R. Srigley, Rajal B. Shah, Toyonori Tsuzuki, Rose Miller, Tipu Nazeer, John C. Cheville, Andrew Evans, Ying-Bei Chen, Steven S. Shen, Ferran Algaba, Marie O'Donnell, Cheng Wang, John N. Nacey, Lars Egevad, James G. Kench, Rafael E. Jimenez, Larry True, Brian D. Robinson, Liang Cheng, Maria Shevchuk, Masoumeh Ghayouri, Robert W. Allan, Stewart Fleming, Cristina Magi-Galluzzi, Antonio Lopez-Beltran, Ahmed Shabaik, Anil V. Parwani, Debra L. Zynger, Funda Vakar-Lopez, Dilek Ertoy Baydar, Louis R. Bégin, Mathilde Sibony, Giovanna A. Giannico, Joan Sweet, Wei Huang, Samson W. Fine, Claudio Lewin, Ruth Birbe, Henry Crist, Jonathan H Shanks, Peter A. Humphrey, George J. Netto, Edward C. Jones, Fadi Brimo, Jiaoti Huang, Zhaoli Lane, Peter Bethwaite, Roberto Orozco, Satish K. Tickoo, Eddie Fridman, Maria Merino, Masoud Ganji, Chin Chen Pan, Hiroyuki Takahashi, Aysim Ozagari, Brett Delahunt, Nathalie Rioux-Leclercq, Adebowale J. Adeniran, Teresa McHale, Kathrine Lie, Maria Pyda-Karwicka, David J. Grignon, Warick Delprado, Stephen M. Bonsib, Victor E. Reuter, Yong Mee Cho, Mathieu Latour, Hiroshi Miyamoto, Theo H. van der Kwast, Jin Zhao, Sara M. Falzarano, Masatoshi Kida, Fiona Maclean, Jorge L. Yao, Maria M. Picken, Laurie Russell, Hedwig Murphy, Kenneth A. Iczkowski, Daniel M. Berney, Sueli Suzigan, Helen P. Cathro, Glen Kristiansen, Jonathan I. Epstein, Ulrika Axcrona, Christina Hulsbergen Van De Kaa, Lakshmi P. Kunju, Adeboye O. Osunkoya, David J. Griffiths, Anila Abraham, Fang Ming Deng, Marc Barry |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
American Journal of Surgical Pathology. 37:1490-1504 |
| ISSN: |
0147-5185 |
| Popis: |
The International Society of Urological Pathology 2012 Consensus Conference made recommendations regarding classification, prognostic factors, staging, and immunohistochemical and molecular assessment of adult renal tumors. Issues relating to prognostic factors were coordinated by a workgroup who identified tumor morphotype, sarcomatoid/rhabdoid differentiation, tumor necrosis, grading, and microvascular invasion as potential prognostic parameters. There was consensus that the main morphotypes of renal cell carcinoma (RCC) were of prognostic significance, that subtyping of papillary RCC (types 1 and 2) provided additional prognostic information, and that clear cell tubulopapillary RCC was associated with a more favorable outcome. For tumors showing sarcomatoid or rhabdoid differentiation, there was consensus that a minimum proportion of tumor was not required for diagnostic purposes. It was also agreed upon that the underlying subtype of carcinoma should be reported. For sarcomatoid carcinoma, it was further agreed upon that if the underlying carcinoma subtype was absent the tumor should be classified as a grade 4 unclassified carcinoma with a sarcomatoid component. Tumor necrosis was considered to have prognostic significance, with assessment based on macroscopic and microscopic examination of the tumor. It was recommended that for clear cell RCC the amount of necrosis should be quantified. There was consensus that nucleolar prominence defined grades 1 to 3 of clear cell and papillary RCCs, whereas extreme nuclear pleomorphism or sarcomatoid and/or rhabdoid differentiation defined grade 4 tumors. It was agreed upon that chromophobe RCC should not be graded. There was consensus that microvascular invasion should not be included as a staging criterion for RCC. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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