Could SARS-CoV-2-induced lung injury be attenuated by vitamin D?
| Autor: | Dezhi Mu, Yi Qu, Xihong Li, Dongqiong Xiao, Xiaojuan Su |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
ARDS ALI acute lung injury viruses medicine.disease_cause Renin-Angiotensin System Pathogenesis 0302 clinical medicine Ang I angiotensin I Acute lung injury Medicine 030212 general & internal medicine Vitamin D skin and connective tissue diseases Receptor Coronavirus TGF-β transforming growth factor β Respiratory Distress Syndrome TNF-α tumour necrosis factor alpha Ang1-7 angiotensin 1-7 RBM receptor-binding motif Type-II Pneumocytes VDREs vitamin D responsive elements virus diseases General Medicine respiratory system HBDs β‐defensins Infectious Diseases Perspective IL-8 inerleukin-8 VDR vitamin D receptor Ang1-9 angiotensin 1-9 Angiotensin-Converting Enzyme 2 hormones hormone substitutes and hormone antagonists Microbiology (medical) 030106 microbiology Lung injury CCL3 chemokine (C-C motif) ligand 3 IFN-α interferon alpha SARS-CoV SARS coronavirus lcsh:Infectious and parasitic diseases hACE2 human ACE2 RBD receptor binding domain 03 medical and health sciences Renin–angiotensin system ACE2 angiotensin converting enzyme-2 Vitamin D and neurology Humans lcsh:RC109-216 Ang Ⅱ angiotensin Ⅱ ARDS acute respiratory distress syndrome AP-1 activation protein 1 SARS-CoV-2 business.industry fungi COVID-19 RAS renin-angiotensin system medicine.disease respiratory tract diseases 2019-nCoV novel coronavirus Immunology RSV respiratory syncytial virus business |
| Zdroj: | International Journal of Infectious Diseases, Vol 102, Iss, Pp 196-202 (2021) International Journal of Infectious Diseases |
| ISSN: | 1201-9712 |
| DOI: | 10.1016/j.ijid.2020.10.059 |
| Popis: | Highlights • As a counter-regulatory arm of the renin-angiotensin system (RAS), ACE2 plays critical roles in the pathogenesis of ARDS and acute lung injury. • The affinity of the spike protein receptor binding domain (RBD) of the SARS-CoV-2 with human ACE2 (hACE2) largely determines the degree of clinical symptoms infected by SARS-CoV-2. • Vitamin D was found to affect ACE2, the same target of SARS-CoV-2, we therefore propose that vitamin D might alleviate ARDS and acute lung injury induced by SARS-CoV-2 through modulating ACE2. A novel coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) has been confirmed to have the capacity to transmit from humans to humans, causing acute respiratory distress syndrome (ARDS) and acute lung injury. Angiotensin converting enzyme-2 (ACE2) has been found to be expressed on type II pneumocytes. As a counterregulatory arm of the renin-angiotensin system (RAS), ACE2 plays critical roles in the pathogenesis of ARDS and acute lung injury. The affinity of the spike protein receptor binding domain (RBD) of SARS-CoV-2 with human ACE2 (hACE2) largely determines the degree of clinical symptoms after infection by SARS-CoV-2. Previous studies have revealed that regulating the ACE2/RAS system was effective in the treatment of severe acute respiratory syndrome coronavirus (SARS-CoV)-induced ARDS and acute lung injury. Since ACE2 is the host cell receptor of both SARS-CoV-2 and SARS-CoV, regulating the ACE2/RAS system may alleviate ARDS and acute lung injury caused by SARS-CoV-2 as well as SARS-CoV. Vitamin D was found to affect ACE2, the target of SARS-CoV-2; therefore, we propose that vitamin D might alleviate ARDS and acute lung injury induced by SARS-CoV-2 by modulating ACE2. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|