Fluticasone propionate–loaded solid lipid nanoparticles with augmented anti-inflammatory activity: optimisation, characterisation and pharmacodynamic evaluation on rats

Autor:	Hossam S. El-Sawy, Mohamed H Desoqi, Mamdouh M. Ghorab, Elsayed Kafagy, Shadeed Gad
Rok vydání:	2021
Předmět:	Male medicine.drug_class Drug Compounding Pharmaceutical Science Bioengineering 02 engineering and technology Pharmacology Carrageenan 030226 pharmacology & pharmacy Dinoprostone Anti-inflammatory Fluticasone propionate 03 medical and health sciences 0302 clinical medicine Colloid and Surface Chemistry Drug Stability Solid lipid nanoparticle medicine Animals Particle Size Rats Wistar Physical and Theoretical Chemistry Inflammation Foot Tumor Necrosis Factor-alpha Chemistry Anti-Inflammatory Agents Non-Steroidal Organic Chemistry 021001 nanoscience & nanotechnology Lipids Box–Behnken design Rats Drug Liberation Pharmacodynamics Fluticasone Nanoparticles 0210 nano-technology medicine.drug
Zdroj:	Journal of Microencapsulation. 38:177-191
ISSN:	1464-5246 0265-2048
Popis:	This work aimed to elaborate an optimised fluticasone propionate (FP)-loaded solid lipid nanoparticles (SLNs) to enhance FP effectiveness for topical inflammatory remediation. The influences of drug amount, lipid, and surfactant ratios, on drug release pattern and stability were investigated utilising Box-Behnken design. Elaboration, characterisation, and pharmacodynamic evaluation in comparison with the marketed formulation (Cutivate® cream, 0.05%
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891382c4eeb2fda429fbeefea36e6f45 https://doi.org/10.1080/02652048.2021.1887383 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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