Histological Osteoarthritic Changes in the Human Cervical Spine Facet Joints Related to Age and Sex
| Autor: | Lars Uhrenholt, Annie Vesterby Charles, Markil Gregersen, Ellen-Margrethe Hauge, Jan Hartvigsen |
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| Rok vydání: | 2017 |
| Předmět: |
musculoskeletal diseases
Adult Cartilage Articular Male Facet (geometry) Cross-sectional study neck pain Autopsy Cervical Vertebrae/pathology Osteoarthritis Cartilage Articular/pathology cervical spine bone Zygapophyseal Joint Facet joint 03 medical and health sciences Young Adult 0302 clinical medicine Sex Factors facet joint medicine Journal Article Humans Orthopedics and Sports Medicine Young adult cartilage Aged 030203 arthritis & rheumatology Orthodontics Neck pain business.industry Cartilage pathogenesis Osteoarthritis Spine/pathology Age Factors Middle Aged medicine.disease Zygapophyseal Joint/pathology osteoarthritis medicine.anatomical_structure Cross-Sectional Studies Cervical Vertebrae Female Osteoarthritis Spine Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Uhrenholt, L, Charles, A V, Gregersen, M, Hartvigsen, J & Hauge, E-M 2018, ' Histological Osteoarthritic Changes in the Human Cervical Spine Facet Joints Related to Age and Sex ', Spine, vol. 43, no. 12, pp. E689-E696 . https://doi.org/10.1097/BRS.0000000000002474 |
| ISSN: | 1528-1159 |
| Popis: | STUDY DESIGN: Cross-sectional autopsy study.OBJECTIVE: Quantify histological changes in the lower cervical spine facet joints with regard to age and gender using systematic random sampling of entire joints.SUMMARY OF BACKGROUND DATA: Neck pain is a common debilitating musculoskeletal condition and one of the highest ranked causes of years lived with disability. The cause of neck pain is multifactorial and osteoarthritis is one potential cause. The cervical spine facet joints have been implicated in the aetiology of chronic neck pain. Hence, a detailed description of their anatomy and age- and gender related changes is needed.METHODS: The lower four cervical spine segments (C4-C7 included) were obtained from 72 subjects during autopsy; 29 females (median age 53 years [22-77]) and 43 males (median age 38 years [20-78]). A total of 1132 articular facets were embedded in toto in hard plastic and sliced into 3-mm thick sections from where 10 μm thick histological sections were produced. Morphological variables were evaluated microscopically and histomorphometric variables were retrieved using random sampling methods. Data were analysed with a linear regression model.RESULTS: Significant associations were found between increasing age and in particular splitting, fissures, osteophytes, thickness of the calcified cartilage and subchondral bone plate. The thickness of the calcified cartilage and subchondral bone plate increased with increasing age whereas the hyaline cartilage thickness decreased. Males had more extensive degenerative changes in the cartilage.CONCLUSIONS: Using semi-quantitative histological methods, degenerative findings were observed at all spinal levels involving the articular cartilage and the osseous structures of the cervical spine facet joints similar to those observed in larger weight bearing joints. In particular, the thickening of the calcified cartilage and the subchondral bone identified the osteocartilaginous junction as an important area in osteoarthritis. These findings may be relevant for the pathogenesis of osteoarthritis.LEVEL OF EVIDENCE: 3. |
| Databáze: | OpenAIRE |
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