Serum 25-hydroxyvitamin D concentration and its association with glucose intolerance in an indigenous population
| Autor: | Amaury Lelis Dal Fabbro, Laércio Joel Franco, João Paulo Botelho Vieira Filho, Giovanna P. Abrahão, Marcia C. dos Santos, Regina S. Moisés |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Population 030209 endocrinology & metabolism Type 2 diabetes Critical Care and Intensive Care Medicine VITAMINA D vitamin D deficiency Body Mass Index Impaired glucose tolerance 03 medical and health sciences 0302 clinical medicine Sex Factors Population Groups Risk Factors Internal medicine Diabetes mellitus Glucose Intolerance medicine Vitamin D and neurology Humans Vitamin D education Aged education.field_of_study 030109 nutrition & dietetics Nutrition and Dietetics business.industry Type 2 Diabetes Mellitus Middle Aged medicine.disease Vitamin D Deficiency Endocrinology Diabetes Mellitus Type 2 Population study Female Waist Circumference business Brazil |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1532-1983 |
| Popis: | Type 2 diabetes is a multifactorial disease resulting from diverse genetic and environmental factors as well as the interaction between them. Low levels of 25-hydroxyvitamin D [25(OH)D], an indicator of vitamin D status, have been associated with an increased risk of type 2 diabetes, but not consistently. Also, it remains to be determined if this association differs among ethnic groups. Therefore, we aimed to evaluate vitamin D status and its association with glucose intolerance in a Brazilian indigenous population, the Xavante Indians.The study population consisted of 819 full Xavante Indians (410 women), aged ≥18 years and living in two indigenous reserves located in Mato Grosso State, central region of Brazil. Clinical examination and anthropometrical measurements were made, blood samples were obtained for total cholesterol, HDL-cholesterol, triglycerides and 25(OH)D measurement. Fasting and 2-h post 75 g oral glucose load capillary glucose was measured. Vitamin D status was defined by serum 25(OH)D levels: vitamin D sufficiency (25(OH)D: 30-100 ng/mL), vitamin D insufficiency (25(OH)D: 20-30 ng/mL) and vitamin D deficiency (25(OH)D:20 ng/mL). Multiple logistic regression was performed to identify independent associations between 25(OH)D levels and impaired glucose tolerance or diabetes mellitus.Analyses stratified by 25(OH)D levels shows that 65.5% of the population had vitamin D deficiency/insufficiency (25(OH)D 30 ng/mL). 25(OH)D concentrations were lower in individuals with impaired glucose tolerance or diabetes mellitus than in normal glucose tolerant individuals. Multiple logistic regression analysis showed an inverse association between increments of 25(OH)D and presence of diabetes mellitus (OR per 1 ng/mL increase in 25(OH)D: 0.97; 95% confidence interval: 0.95-0.99), or impaired glucose tolerance (OR per 1 ng/mL increase in 25(OH)D: 0.87; 95% confidence interval: 0.85-0.89), in an age, sex, BMI and season of sampling-adjusted model.The present population-based study found a high prevalence of hypovitaminosis D among Xavante Indians. In this at-risk population of type 2 diabetes, a significant association of higher serum 25(OH)D with a decreased prevalence of diabetes mellitus and impaired glucose tolerance was observed. |
| Databáze: | OpenAIRE |
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