Effect of Bone-Marrow-Derived Mesenchymal Stem Cells on the Healing of Bone Fractures
| Autor: | Eman M. A. Abdelghany, Shuzan A. Mohammed, Somia H. Abd-Allah, Omnia Youssif Habashy, Samia Hussein, Mahasen Abd Elsattar, Omnia Abdullah |
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| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Immunology Osteocalcin Bone Morphogenetic Protein 2 Bone Marrow Cells Bone healing Bone morphogenetic protein 2 Bone and Bones Fractures Bone Mice Virology Medicine Animals Cells Cultured Fracture Healing Mice Inbred BALB C business.industry Mesenchymal stem cell Cell Differentiation Mesenchymal Stem Cells Cell Biology Bone fracture medicine.disease Alkaline Phosphatase Chemokine CXCL12 medicine.anatomical_structure Female Bone marrow business |
| Zdroj: | Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 41(9) |
| ISSN: | 1557-7465 |
| Popis: | This study was performed to evaluate the effectiveness of mesenchymal stem cells (MSCs) on bone healing and to assess the role of various chemical stimulants and mediators in healing. Forty female mice were randomly assigned to 4 groups (10 mice each) after the induction of fixed fractures: group I: received fixation only; group II: received phosphate-buffered saline (PBS); group III: received intralesion MSCs (IL-MSCs); and group IV: received intraperitoneal MSCs (IP-MSCs). Serum alkaline phosphatase (ALP) levels and the expression of the osteocalcin ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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