Serum Brain-Derived Neurotrophic Factor is Related to Platelet Reactivity but not to Genetic Polymorphisms within BDNF Encoding Gene in Patients with Type 2 Diabetes

Autor: Piotr K. Janicki, Grzegorz Opolski, Krzysztof J. Filipiak, A Cudna, Małlgorzata Zaremba, Marek Postuła, Ceren Eyileten, Agnieszka Kapłon-Cieślicka, Dariusz A. Kosior, Marek Rosiak, Dagmara Mirowska-Guzel
Rok vydání: 2016
Předmět:
Blood Platelets
Male
Quality Control
0301 basic medicine
Genotype
Platelet Function Tests
Mutation
Missense
Type 2 diabetes
Biology
Polymorphism
Single Nucleotide
03 medical and health sciences
Clinical Research
Neurotrophic factors
Diabetes mellitus
0502 economics and business
Diabetes Mellitus
medicine
Humans
SNP
Genetic Predisposition to Disease
Prospective Studies
Platelet activation
Prospective cohort study
Alleles
Aged
Retrospective Studies
Inflammation
Brain-derived neurotrophic factor
Aspirin
Interleukin-6
Brain-Derived Neurotrophic Factor
05 social sciences
General Medicine
Middle Aged
Platelet Activation
medicine.disease
Introns
P-Selectin
030104 developmental biology
Diabetes Mellitus
Type 2
Gene Expression Regulation
Multivariate Analysis
Immunology
Female
050211 marketing
rs6265
Zdroj: Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
ISSN: 1643-3750
Popis: Background The aim of this study was to investigate the association between serum concentrations of the brain-derived neurotrophic factor (BDNF), platelet reactivity and inflammatory markers, as well as its association with BDNF encoding gene variants in type 2 diabetic patients (T2DM) during acetylsalicylic acid (ASA) therapy. Material/Methods This retrospective, open-label study enrolled 91 patients. Serum BDNF, genotype variants, hematological, biochemical, and inflammatory markers were measured. Blood samples were taken in the morning 2–3 h after the last ASA dose. The BDNF genotypes for selected variants were analyzed by use of the iPLEX Sequenom assay. Results In multivariate linear regression analysis, CADP-CT >74 sec (p74 sec (p=0.02) and IL-6 concentration (p=0.03) were risk factors for serum BDNF above the median. Non-significant differences were observed between intronic SNP rs925946, missense SNP rs6265, and intronic SNP rs4923463 allelic groups and BDNF concentrations in the investigated cohort. Conclusions Chronic inflammatory condition and enhanced immune system are associated with the production of BDNF, which may be why the serum BDNF level in T2DM patients with high platelet reactivity was higher compared to subjects with normal platelet reactivity in this study.
Databáze: OpenAIRE
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