Serum Brain-Derived Neurotrophic Factor is Related to Platelet Reactivity but not to Genetic Polymorphisms within BDNF Encoding Gene in Patients with Type 2 Diabetes
Autor: | Piotr K. Janicki, Grzegorz Opolski, Krzysztof J. Filipiak, A Cudna, Małlgorzata Zaremba, Marek Postuła, Ceren Eyileten, Agnieszka Kapłon-Cieślicka, Dariusz A. Kosior, Marek Rosiak, Dagmara Mirowska-Guzel |
---|---|
Rok vydání: | 2016 |
Předmět: |
Blood Platelets
Male Quality Control 0301 basic medicine Genotype Platelet Function Tests Mutation Missense Type 2 diabetes Biology Polymorphism Single Nucleotide 03 medical and health sciences Clinical Research Neurotrophic factors Diabetes mellitus 0502 economics and business Diabetes Mellitus medicine Humans SNP Genetic Predisposition to Disease Prospective Studies Platelet activation Prospective cohort study Alleles Aged Retrospective Studies Inflammation Brain-derived neurotrophic factor Aspirin Interleukin-6 Brain-Derived Neurotrophic Factor 05 social sciences General Medicine Middle Aged Platelet Activation medicine.disease Introns P-Selectin 030104 developmental biology Diabetes Mellitus Type 2 Gene Expression Regulation Multivariate Analysis Immunology Female 050211 marketing rs6265 |
Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
ISSN: | 1643-3750 |
Popis: | Background The aim of this study was to investigate the association between serum concentrations of the brain-derived neurotrophic factor (BDNF), platelet reactivity and inflammatory markers, as well as its association with BDNF encoding gene variants in type 2 diabetic patients (T2DM) during acetylsalicylic acid (ASA) therapy. Material/Methods This retrospective, open-label study enrolled 91 patients. Serum BDNF, genotype variants, hematological, biochemical, and inflammatory markers were measured. Blood samples were taken in the morning 2–3 h after the last ASA dose. The BDNF genotypes for selected variants were analyzed by use of the iPLEX Sequenom assay. Results In multivariate linear regression analysis, CADP-CT >74 sec (p74 sec (p=0.02) and IL-6 concentration (p=0.03) were risk factors for serum BDNF above the median. Non-significant differences were observed between intronic SNP rs925946, missense SNP rs6265, and intronic SNP rs4923463 allelic groups and BDNF concentrations in the investigated cohort. Conclusions Chronic inflammatory condition and enhanced immune system are associated with the production of BDNF, which may be why the serum BDNF level in T2DM patients with high platelet reactivity was higher compared to subjects with normal platelet reactivity in this study. |
Databáze: | OpenAIRE |
Externí odkaz: |