Gut microbiota community characteristics and disease-related microorganism pattern in a population of healthy Chinese people
| Autor: | Yujun Qiang, Ming Hu, Ling Zhang, Xianhui Peng, Biao Kan, Qun Li, Yuqing Liu, Na Han, Qing Zhang, Xi Chen, Hong Wang, Jie Che, Shan Lu, Xia Chen, Tingting Zhang, Jiaojiao Miao, Yanhua Kong, Wen Zhang, Xiuwen Li, Xiaofei Zhao, Juan Li, Tongxin Gao |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine China Adolescent Population lcsh:Medicine Biology Gut flora Article Feces Young Adult 03 medical and health sciences 0302 clinical medicine Environmental health Flora (microbiology) Humans Disease Microbiome lcsh:Science education education.field_of_study Multidisciplinary lcsh:R Gastrointestinal Microbiome Middle Aged biology.organism_classification Healthy Volunteers Chinese people 030104 developmental biology Metagenomics lcsh:Q Female Body mass index 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-018-36318-y |
| Popis: | China’s population accounts for about 1/5th of the world’s total population. Owing to differences in environment, race, living habits, and other factors, the structure of the intestinal flora of Chinese individuals is expected to have unique features; however, this has not been thoroughly examined. Here, we collected faecal samples from healthy adults living in three cities of China and investigated their gut microbiome using metagenomics and bioinformatics technology. We found that 11 core bacterial genera were present in all of the Chinese faecal samples; moreover, several patient characteristics (age, region, body mass index, physical exercise, smoking habits, and alcoholic drink, and yogurt consumption) were found to have different effects on the gut microbiome of healthy Chinese people. We also examined the distribution patterns of disease-related microorganisms (DRMs), revealing which DRMs can potentially be used as markers for assessment of health risk. We also developed a program called “Guthealthy” for evaluating the health status associated with the microbiome and DRM pattern in the faecal samples. The microbiota data obtained in this study will provide a basis for a healthy gut microbiome composition in the Chinese population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|