Incidence of SARS-CoV-2 in people with cystic fibrosis in Europe between February and June 2020

Autor: Halyna Makukh, Andrea Dugac Vukic, Meir Mei-Zahav, Tsitsino Parulava, Harriet Corvol, Godfrey Fletcher, Rita Padoan, S. Fustik, Silke van Koningsbruggen-Rietschel, Fiona Dunlevy, Andreas Jung, Hana Kayserova, Satenik Harutyunyan, Siobhán B. Carr, Domenique Zomer-van Ommen, Łukasz Woźniacki, Svetlana Keegan, Elena Kondratyeva, Jacqui G. van Rens, Elpis Hatziagorou, Carla Colombo, Pedro Mondejar-Lopez, Vincent Gulmans, Anita Senstad Wathne, María Dolores Pastor-Vivero, Milan Macek, Egil Bakkeheim, Milan Rodić, Sevgi Pekcan, Filia Diamantea, Elliott McClenaghan, Géraldine Daneau, Guergana Petrova, Kęstutis Malakauskas, Marko Krasnyk, Yasemin Gokdemir, Panayiotis K. Yiallouros, Elise Lammertyn, Marc Schlesser, Edward F. McKone, Andreas Pfleger, Olga I. Simonova, Luísa Pereira, Elena Zhekaite, Anders Lindblad, Oxana Turcu, Andrea Párniczky, Isabelle de Monestrol, Duška Tješić-Drinković, Elina Aleksejeva, Uro Krivecs, Lutz Naehrlich, Elena Amelina, A. Zolin, Pierre-Régis Burgel, Vladimir Bobrovnichy, Annalisa Orenti, Alena Bilkova, Deniz Dogru, Liviu Pop, Marco Salvatore, Nataliya Kashirskaya, Irena Kasmi, Keith G. Brownlee, Pavel Drevinek, Hanne Vebert Olesen, Rebecca Cosgriff, Lydie Lemonnier-Videau, A. Fox, Ivan Bambir
Přispěvatelé: Naehrlich, Lutz, Orenti, Annalisa, Dunlevy, Fiona, Kasmi, Irena, Harutyunyan, Satenik, Pfleger, Andreas, Keegan, Svetlana, Daneau, Geraldine, Petrova, Guergana, Tjesic-Drinkovic, Duska, Yiallouros, Panayioti, Bilkova, Alena, Olesen, Hanne Vebert, Burgel, Pierre-Regis, Parulava, Tsitsino, Diamantea, Filia, Parniczky, Andrea, McKone, Edward F., Mei-Zahav, Meir, Salvatore, Marco, Colombo, Carla, Aleksejeva, Elina, Malakauskas, Kestutis, Schlesser, Marc, Fustik, Stojka, Turcu, Oxana, Zomer-van Ommen, Domenique, Wathne, Anita Senstad, Wozniacki, Lukasz, Pereira, Luisa, Pop, Liviu, Kashirskaya, Nataliya, Rodic, Milan, Kayserova, Hana, Krivecs, Uro, Mondejar-Lopez, Pedro, de Monsterol, Isabelle, Dogru, Deniz, Makukh, Halyn, Cosgriff, Rebecca, van Koningsbruggen-Rietschel, Silke, Jung, Andreas, Bobrovnichy, Vladimir, Bambir, Ivan, Vukic, Andrea Dugac, Drevinek, Pavel, Macek, Milan, Jr., Corvol, Harriet, Lemonnier-Videau, Lydie, Hatziagorou, Elpis, Fletcher, Godfrey, Padoan, Rita, Gulmans, Vincent, Bakkeheim, Egil, Kondratyeva, Elena, Amelina, Elena, Zhekaite, Elena, Simonova, Olga, Pastor-Vivero, Maria Dolores, Lindblad, Anders, Gokdemir, Yasemin, Pekcan, Sevgi, Brownlee, Keith, McClenaghan, Elliot, Carr, Siobhan, Lammertyn, Elise, Zolin, Anna, Fox, Alice, Krasnyk, Marko, Van Rens, Jacqui
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Male
COVID-19/diagnosis
IMPACT
Epidemiology
Cystic fibrosis
0302 clinical medicine
Cystic Fibrosis/complications
Case fatality rate
Medicine
Registries
Child
education.field_of_study
Incidence (epidemiology)
Incidence
Middle Aged
Vaccination
Europe
Hospitalization
medicine.anatomical_structure
Child
Preschool
Female
Covid-19
Lung Transplantation
Pulmonary and Respiratory Medicine
Adult
medicine.medical_specialty
Adolescent
Critical Care
Population
Article
Europe/epidemiology
03 medical and health sciences
Young Adult
Intensive care
Internal medicine
Humans
education
Retrospective Studies
Lung
business.industry
SARS-CoV-2
Infant
Newborn
Infant
medicine.disease
cystic fibrosis
incidence
epidemiology
Transplantation
030104 developmental biology
030228 respiratory system
Pediatrics
Perinatology and Child Health
business
Zdroj: Naehrlich, L, Orenti, A, Dunlevy, F, Kasmi, I, Harutyunyan, S, Pfleger, A, Keegan, S, Daneau, G, Petrova, G, Tješić-Drinković, D, Yiallouros, P, Bilkova, A, Olesen, H V, Burgel, P R, Parulava, T, Diamantea, F, Párniczky, A, McKone, E F, Mei-Zahav, M, Salvatore, M, Colombo, C, Aleksejeva, E, Malakauskas, K, Schlesser, M, Fustik, S, Turcu, O, Zomer-van Ommen, D, Wathne, A S, Woźniacki, Ł, Pereira, L, Pop, L, Kashirskaya, N, Rodić, M, Kayserova, H, Krivecs, U, Mondejar-Lopez, P, de Monestrol, I, Dogru, D, Makukh, H, Cosgriff, R, van Koningsbruggen-Rietschel, S, Jung, A & European Cystic Fibrosis COVID project group 2021, ' Incidence of SARS-CoV-2 in people with cystic fibrosis in Europe between February and June 2020 ', Journal of Cystic Fibrosis, vol. 20, no. 4, pp. 566-577 . https://doi.org/10.1016/j.jcf.2021.03.017
Journal of Cystic Fibrosis
ISSN: 1569-1993
DOI: 10.1016/j.jcf.2021.03.017
Popis: Background: Viral infections can cause significant morbidity in cystic fibrosis (CF). The current Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic could therefore have a serious impact on the health of people with CF (pwCF). Methods: We used the 38-country European Cystic Fibrosis Society Patient Registry (ECFSPR) to collect case data about pwCF and SARS-CoV-2 infection. Results: Up to 30 June 2020, 16 countries reported 130 SARS-CoV-2 cases in people with CF, yielding an incidence of 2.70/10 0 0 pwCF. Incidence was higher in lung-transplanted patients (n = 23) versus non transplanted patients (n = 107) (8.43 versus 2.36 cases/10 0 0). Incidence was higher in pwCF versus the age-matched general population in the age groups < 15, 15-24, and 25-49 years (p < 0.001), with similar trends for pwCF with and without lung transplant. Compared to the general population, pwCF (regardless of transplantation status) had significantly higher rates of admission to hospital for all age groups with available data, and higher rates of intensive care, although not statistically significant. Most pwCF recovered (96.2%), however 5 died, of whom 3 were lung transplant recipients. The case fatality rate for pwCF (3.85%, 95% CI: 1.26-8.75) was non-significantly lower than that of the general population (7.46%; p = 0.133). Conclusions: SARS-CoV-2 infection can result in severe illness and death for pwCF, even for younger patients and especially for lung transplant recipients. PwCF should continue to shield from infection and should be prioritized for vaccination. (c) 2021 The Authors. Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
Databáze: OpenAIRE
Externí odkaz: