Control of seizures in different stages of partial epilepsy: LACO-EXP, a Spanish retrospective study of lacosamide
| Autor: | J C Sánchez-Alvarez, Vicente Villanueva, Manuel Toledo, Pedro J. Serrano-Castro, Pilar de la Peña, Dulce Campos, Montserrat Asensio, Juan Jesús Rodríguez Uranga, Rosa Ana Saiz-Díaz, José M. Serratosa, Antonio Moreno, José Ángel Mauri, Beatriz González-Giráldez, Albert Molins, Francisco Javier López, Javier Salas-Puig, Jesús González de la Aleja |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Time Factors Adolescent Lacosamide Observation Statistics Nonparametric Young Adult Behavioral Neuroscience Epilepsy Acetamides medicine Humans Adverse effect Aged Retrospective Studies Partial epilepsy Aged 80 and over business.industry Retrospective cohort study Middle Aged medicine.disease Treatment Outcome Neurology Tolerability Spain Concomitant Anesthesia Anticonvulsants Female Observational study Epilepsies Partial Neurology (clinical) business Follow-Up Studies medicine.drug |
| Zdroj: | Epilepsy & Behavior. 29:349-356 |
| ISSN: | 1525-5050 |
| DOI: | 10.1016/j.yebeh.2013.07.024 |
| Popis: | Lacosamide is approved as adjunctive therapy for focal epilepsies. The number of antiepileptic drugs (AEDs) tried is associated with prognosis. This multicenter, retrospective, observational study (LACO-EXP) in Spain in 500 adult patients with focal epilepsies examined the efficacy and tolerability of add-on lacosamide. Factors associated with better efficacy/tolerability were analyzed. After 12months, the responder rate (≥50% reduction in seizure frequency) was 57.1%, and the seizure-free rate was 14.9%. Efficacy was better when lacosamide was the first or second add-on AED, although there was a small chance to be seizure-free even for patients who had received ≤10 prior AEDs. The mechanism of action of concomitant AEDs is important in all the stages, but differences are smaller in the early stages. Lacosamide was generally well tolerated. A slower dosage-titration schedule was associated with a lower adverse event rate. Further investigation of the timing of initiation of lacosamide add-on therapy and ideal combinations of AEDs is required. |
| Databáze: | OpenAIRE |
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