The spatial orientation of Helicobacter pylori in the gastric mucus
| Autor: | Claudia Groll, Hans-Otto Werling, Christine Josenhans, Sören Schreiber, Manuela Konradt, Peter Scheid, Guido Hanauer, Sebastian Suerbaum |
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| Rok vydání: | 2004 |
| Předmět: |
Bicarbonate
Microbiology Mice chemistry.chemical_compound Gastric mucosa medicine Animals Urea Helicobacter Electrochemical gradient Multidisciplinary Helicobacter pylori biology Chemotaxis Biological Sciences Carbon Dioxide Hydrogen-Ion Concentration biology.organism_classification Mucus Quaternary Ammonium Compounds Bicarbonates medicine.anatomical_structure chemistry Gastric Mucosa Female Bacteria |
| Zdroj: | Proceedings of the National Academy of Sciences. 101:5024-5029 |
| ISSN: | 1091-6490 0027-8424 |
| Popis: | The highly motile human pathogen Helicobacter pylori lives deep in the gastric mucus layer. To identify which chemical gradient guides the bacteria within the mucus layer, combinations of luminal perfusion, dialysis, and ventilation were used to modify or invert transmucus gradients in anaesthetized Helicobacter -infected mice and Mongolian gerbils. Neither changes in lumen or arterial pH nor inversion of bicarbonate/CO 2 or urea/ammonium gradients disturbed Helicobacter orientation. However, elimination of the mucus pH gradient by simultaneous reduction of arterial pH and bicarbonate concentration perturbed orientation, causing the bacteria to spread over the entire mucus layer. H. pylori thus uses the gastric mucus pH gradient for chemotactic orientation. |
| Databáze: | OpenAIRE |
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