THE α1b-ADRENERGIC RECEPTOR SUBTYPE: MOLECULAR PROPERTIES AND PHYSIOLOGICAL IMPLICATIONS
| Autor: | Peter J. Greasley, Laura Stanasila, Susanna Cotecchia, Olivier Rossier, Francesca Fanelli, Katja Björklöf |
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| Rok vydání: | 2002 |
| Předmět: |
Adrenergic receptor
GPCRs computational modeling molecular simulations constitutively active mutants glycoprotein hormone receptors Mutagenesis (molecular biology technique) Blood Pressure Pharmacology Biology Biochemistry Receptor subtype Mice Receptors Adrenergic alpha-1 Animals Homeostasis Humans Glucose homeostasis Phosphorylation Receptor Molecular Biology G protein-coupled receptor Mice Knockout Cell Biology Glucose Knockout mouse Adrenergic alpha-Agonists Receptor activation Neuroscience Signal Transduction |
| Zdroj: | Journal of Receptors and Signal Transduction. 22:1-16 |
| ISSN: | 1532-4281 1079-9893 |
| Popis: | The aim of this review is to summarize some of the main findings from our laboratory as well as from others concerning the biochemical, molecular, and functional properties of the alpha1b-adrenergic receptor. Experimental and computational mutagenesis of the alpha1b-adrenergic receptor have been instrumental in elucidating some of the molecular mechanisms underlying receptor activation and receptor coupling to Gq. The knockout mouse model lacking the alpha1b-adrenergic receptor has highlighted the potential implication of this receptor subtype in variety of functions including the regulation of blood pressure, glucose homeostasis, and the rewarding response to drugs of abuse. |
| Databáze: | OpenAIRE |
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