Racial differences in bumetanide-sensitive cotransport and N-ethylmaleimide-stimulated potassium efflux
| Autor: | Alan B. Weder, Barbara A. Torretti |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Nystatin
medicine.medical_specialty Erythrocytes medicine.medical_treatment Sodium Potassium Black People chemistry.chemical_element In Vitro Techniques White People General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Internal medicine medicine Humans heterocyclic compounds General Pharmacology Toxicology and Pharmaceutics Diuretics Ouabain Bumetanide Chemistry Racial Groups N-Ethylmaleimide Biological Transport General Medicine Red blood cell Endocrinology medicine.anatomical_structure Biochemistry Ethylmaleimide Efflux Diuretic Cotransporter medicine.drug |
| Zdroj: | Life Sciences. 36:1813-1818 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(85)90153-5 |
| Popis: | Racial differences in erythrocyte potassium effluxes mediated by two loop-diuretic sensitive modes of cotransport were compared. In red cells loaded to contain approximately equimolar amounts of sodium and potassium, black subjects had lower bumetanide-sensitive sodium-dependent net potassium effluxes as compared to whites. In fresh, washed erythrocytes pretreated with N-ethylmaleimide (NEM), maximal net potassium efflux was greater in blacks than in whites. NEM-stimulated potassium efflux was partially inhibited by bumetanide but only at very high concentrations. The quantitative differences in these two modes of potassium efflux suggest that NEM-stimulated potassium efflux is not an altered mode of sodium-dependent potassium efflux. |
| Databáze: | OpenAIRE |
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