Critical periods regulating the circuit integration of adult-born hippocampal neurons
| Autor: | Hannah M. Jahn, Matteo Bergami |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
0301 basic medicine Aging Time Factors Histology Neurogenesis Biology Hippocampal formation Pathology and Forensic Medicine Mice 03 medical and health sciences 0302 clinical medicine ddc:570 Neuroplasticity Network level Connectome Animals Humans Maturation process Neurons Neuronal Plasticity Dentate gyrus Cell Biology CA3 Region Hippocampal 030104 developmental biology Dentate Gyrus Models Animal Synaptic plasticity Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Cell and Tissue Research |
| Popis: | The dentate gyrus (DG) in the adult brain maintains the capability to generate new granule neurons life-long. Neural stem cell-derived new-born neurons are emerging for playing key functions in the way information is processed in the DG and then conveyed to the CA3 hippocampal area, yet accumulating evidence indicates that both the maturation process and the connectivity pattern of new granule neurons are not prefigured, but can be modulated by the activity of local microcircuits and, on a network level, by experience. Although most of the so-far described activity- and experience-dependent changes appear to be restricted to critical periods during the development of new granule neurons, it is becoming increasingly clear that the surrounding circuits may play equally key roles in accommodating, and perhaps fostering, these changes. Here, we review some of the most recent insights into this almost unique form of plasticity in the adult brain by focussing on those critical periods marked by pronounced changes in structure and function of the new granule neurons, and discuss how the activity of putative synaptic partners may contribute to shape the circuit module in which new neurons become finally integrated. |
| Databáze: | OpenAIRE |
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