Selected tumour biomarker levels in sheep with pulmonary adenomatosis
| Autor: | Zübeyir Huyut, Mustafa Özbek, Cumali Özkan, Serkan Yildirim |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
sheep
medicine.medical_specialty Pulmonary Adenomatosis diagnosis 040301 veterinary sciences Veterinary medicine Review Article Gastroenterology 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Carcinoembryonic antigen Statistical significance Internal medicine SF600-1100 Medicine pulmonary adenomatosis General Veterinary biology business.industry 04 agricultural and veterinary sciences Jaagsiekte sheep retrovirus biology.organism_classification Vaccination 030220 oncology & carcinogenesis biology.protein Biomarker (medicine) tumour biomarkers business Alpha-fetoprotein Carbohydrate antigen |
| Zdroj: | Journal of Veterinary Research Journal of Veterinary Research, Vol 64, Iss 1, Pp 39-44 (2020) |
| ISSN: | 2450-8608 |
| DOI: | 10.2478/jvetres-2020-0017 |
| Popis: | Introduction Sheep pulmonary adenomatosis (ovine pulmonary adenomatosis, OPA, Jaagsiekte) is a chronic contagious bronchoalveolar carcinoma caused by the Jaagsiekte sheep retrovirus. Since effective treatment and a vaccination procedure are not currently possible, control and eradication of the disease is difficult. It leads to serious economic losses around the world, therefore studies are currently underway in order to design control and eradication programmes. In this study, levels and changes in selected tumour markers (carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 125, CA 19-9, CA 15-3, and alphafetoprotein (AFP)-3) and their diagnostic significance were investigated. Material and Methods A total of 30 sheep were used. Clinical examinations were performed and blood samples were obtained before slaughter from all animals with presumed OPA. Blood samples with positive OPA results by macroscopic and histopathological examination were included in the study as the experimental group and numbered 20. Sheep totalling 10 had negative OPA results and provided control samples. Results CEA levels were similar in both groups, and the differences were statistically insignificant (P > 0.05). CA 125, CA 19-9, CA 15-3, and AFP-3 levels were higher in the OPA group than the control group and with statistical significance (P < 0.05). In all OPA animals, CA 125 levels were higher than 1 U/mL. Conclusion serum CAs and AFP levels increase significantly in adenomatous sheep. These tumour markers are thought to facilitate the diagnosis of OPA. |
| Databáze: | OpenAIRE |
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