Clonal Expansion of Hypermutated Measles Virus in a SSPE Brain
| Autor: | Uwe G. Liebert, K. Baczko, S. Isserte, V ter Meulen, H. Budka, Bertus K. Rima, Sara Louise Cosby, U. Brinckmann, I. Pardowitz, J. Lampe |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
DNA Complementary Genes Viral Paramyxoviridae Sequence analysis Molecular Sequence Data Gene Expression Somatic hypermutation Subacute sclerosing panencephalitis Virus Viral Matrix Proteins Measles virus Morbillivirus Virology medicine Humans Point Mutation RNA Messenger Cloning Molecular Gene In Situ Hybridization Genetics Base Sequence biology Brain RNA Probes medicine.disease biology.organism_classification DNA Viral Female Subacute Sclerosing Panencephalitis Oligonucleotide Probes |
| Zdroj: | Backzko, K, Lampe, J, Liebert, U G, Brinckmann, U, Ter Meulen, V, Pardowitz, I, Budka, H, Cosby, S L, Isserte, S & Rima, B K 1993, ' Clonal expansion of hypermutated measles virus in a SSPE brain ' Virology, vol 197, no. 1, pp. 188-195 ., 10.1006/viro.1993.1579 |
| ISSN: | 0042-6822 |
| DOI: | 10.1006/viro.1993.1579 |
| Popis: | Nucleotide sequence analysis was carried out to study genes encoding the matrix (M) protein of measles virus (MV) from several regions of the brain of a case of subacute sclerosing panencephalitis. This analysis revealed the presence of MV with 'wild-type' sequences as well as variants which had undergone at least five biased hypermutation events (U to C and A to G in the positive strand sequences). Despite the presence of MV variants with genes encoding the intact matrix protein open reading frame, M protein could not be detected in any of the brain regions. The distribution of virus variants was studied by cDNA cloning and sequence analysis and by in situ hybridization. The hypermutated viruses appeared to expand clonally throughout the brain of patient B. |
| Databáze: | OpenAIRE |
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