Protein condensates as aging Maxwell fluids
| Autor: | Elisabeth Fischer-Friedrich, Anthony A. Hyman, Frank Jülicher, Mahdiye Ijavi, Suropriya Saha, Jie Wang, Julia Mahamid, Titus M. Franzmann, Jenny Sachweh, Shambaditya Saha, Louise Jawerth, Martine Ruer, Xiaojie Zhang |
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| Jazyk: | angličtina |
| Předmět: |
0303 health sciences
Multidisciplinary Materials science Viscosity Proteins 01 natural sciences Viscoelasticity Solutions 03 medical and health sciences Optical tweezers Rheology Hardness Chemical physics 0103 physical sciences 010306 general physics Material properties Elastic modulus 030304 developmental biology Complex fluid |
| Zdroj: | Science |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.aaw4951 |
| Popis: | Rheology of aging protein condensates Protein condensates that form by undergoing liquid-liquid phase separation will show changes in their rheological properties with time, a process known as aging. Jawerth et al. used laser tweezer–based active and microbead-based passive rheology to characterize the time-dependent material properties of protein condensates (see the Perspective by Zhang). They found that condensate aging is not gelation of the condensates, but rather a changing viscoelastic Maxwell liquid with a viscosity that strongly increases with age, whereas the elastic modulus stays the same. Science , this issue p. 1317 ; see also p. 1271 |
| Databáze: | OpenAIRE |
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