Elevated micronuclei frequency in type 2 diabetes with high glycosylated hemoglobin
| Autor: | Suresh K. G. Shettigar, C. Shailaja, Ratnakar K. Kulkarni |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Glycosylation Endocrinology Diabetes and Metabolism Type 2 diabetes medicine.disease_cause complex mixtures chemistry.chemical_compound Endocrinology Diabetes mellitus Internal medicine Internal Medicine medicine Humans Micronuclei Chromosome-Defective Whole blood Glycated Hemoglobin Micronucleus Tests business.industry General Medicine Middle Aged medicine.disease Oxidative Stress Diabetes Mellitus Type 2 chemistry Hyperglycemia Micronucleus test Biomarker (medicine) Female Hemoglobin business Biomarkers Oxidative stress DNA Damage |
| Zdroj: | Diabetes Research and Clinical Practice. 95:246-250 |
| ISSN: | 0168-8227 |
| DOI: | 10.1016/j.diabres.2011.10.025 |
| Popis: | Aim The role of oxidative damage to DNA due to hyperglycemia is well known. In the current study we have evaluated the induction of micronuclei due to increased glycosylation in type 2 diabetes. Methods Forty-nine subjects divided into two groups of normoglycemic controls and type 2 diabetic cases were recruited in the study. Whole blood was cultured and micronuclei were scored in all the cases. This was correlated with age, sex, blood glucose levels and glycosylated hemoglobin. Results Age and sex matched diabetic patients had an increased micronuclei frequency in response to elevated glycosylation of hemoglobin ( R 2 = 0.229, p = 0.037) compared to normoglycemic subjects. Conclusion The increased glycosylation seems to induce oxidative damage in the DNA of the diabetic patients, which manifests as an increased micronuclei frequency. This has a potential to be used as a biomarker for subsequent diabetic complications. |
| Databáze: | OpenAIRE |
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