Adoptive immunotherapy of cancer: biological response modifiers and cytotoxic cell therapy
| Autor: | Gabriel P. Haas, Werner H. Wahl, Denis M. Callewaert, Gilda G. Hillman |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Pharmacology
Adoptive cell transfer Lymphokine-activated killer cell business.industry Tumor-infiltrating lymphocytes medicine.medical_treatment Lymphokine Antineoplastic Agents Immunotherapy Combined Modality Therapy Immunotherapy Adoptive Immune system Cancer immunotherapy Neoplasms Immunology Animals Humans Immunologic Factors Medicine Biological response modifiers business |
| Zdroj: | Biotherapy. 5:119-129 |
| ISSN: | 1573-8280 0921-299X |
| DOI: | 10.1007/bf02171697 |
| Popis: | Immunotherapy has been developed for the treatment of metastatic cancers refractory to conventional therapies. Immunotherapy utilizes immune cells and/or biological response modifiers (BRMs) to induce an anti-tumor response mediated by the patient's immune system. BRMs, including lymphokines and cytokines, are used as single agents or in combination for cancer therapy. Some BRMs, particularly interleukin 2 (IL-2), can activate and expand in vitro lymphocytes with anti-tumor reactivity which will be adoptively transferred to the patient. To enhance the therapeutic effect of immunotherapy, gene therapy is currently under investigation and involves the insertion of cytokine genes in immune cells or in tumor cells. The development and future of cancer immunotherapy will be discussed in this review. |
| Databáze: | OpenAIRE |
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