Pharmacokinetics and pharmacodynamics of enalapril and its active metabolite, enalaprilat, at four different doses in healthy horses
| Autor: | Manuel Gómez-Díez, Juan Manuel Serrano Caballero, Cristina Riber, Juan Manuel Serrano-Rodríguez, Francisco Castejón, Ana Muñoz |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Enalaprilat
Administration Oral Angiotensin-Converting Enzyme Inhibitors Blood Pressure Pharmacology Statistics Nonparametric Blood Urea Nitrogen chemistry.chemical_compound Enalapril Pharmacokinetics medicine Animals Horses cardiovascular diseases Blood urea nitrogen Active metabolite Creatinine Cross-Over Studies Dose-Response Relationship Drug integumentary system General Veterinary business.industry Crossover study chemistry Pharmacodynamics Administration Intravenous business Half-Life circulatory and respiratory physiology medicine.drug |
| Zdroj: | Research in Veterinary Science. 97:105-110 |
| ISSN: | 0034-5288 |
| DOI: | 10.1016/j.rvsc.2014.06.006 |
| Popis: | Pharmacokinetic and pharmacodynamic of IV enalapril at 0.50 mg/kg, PO placebo and PO enalapril at three different doses (0.50, 1.00 and 2.00 mg/kg) were analyzed in 7 healthy horses. Serum concentrations of enalapril and enalaprilat were determined for pharmacokinetic analysis. Angiotensin-converting enzyme (ACE) activity, serum ureic nitrogen (SUN), creatinine and electrolytes were measured, and blood pressure was monitored for pharmacodynamic analysis. The elimination half-lives of enalapril and enalaprilat were 0.67 and 2.76 h respectively after IV enalapril. Enalapril concentrations after PO administrations were below the limit of quantification (10 ng/ml) in all horses and enalaprilat concentrations were below the limit of quantification in 4 of the 7 horses. Maximum mean ACE inhibitions from baseline were 88.38, 3.24, 21.69, 26.11 and 30.19% for IV enalapril at 0.50 mg/kg, placebo and PO enalapril at 0.50, 1.00 and 2.00 mg/kg, respectively. Blood pressures, SUN, creatinine and electrolytes remained unchanged during the experiments. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect