Patterns of Care and Survival for Elderly Acute Myeloid Leukemia—Challenges and Opportunities
| Autor: | Abhishek A. Mangaonkar, Mrinal M. Patnaik |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Cancer Research
medicine.medical_specialty Health Services for the Aged Biological age Population Antineoplastic Agents Disease 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans education Intensive care medicine Aged Aged 80 and over Patterns of care education.field_of_study Hematology business.industry Myeloid leukemia Survival Rate Clinical trial Oncology Leukemia Myeloid 030220 oncology & carcinogenesis Acute Disease Quality of Life Objective risk business Stem Cell Transplantation 030215 immunology |
| Zdroj: | Current Hematologic Malignancy Reports. 12:290-299 |
| ISSN: | 1558-822X 1558-8211 |
| Popis: | Acute myeloid leukemia (AML) is a disease of the elderly, with a median age of diagnosis in the sixth decade of life. Mortality has declined over the last few years, but this impact is apparent only in the young, fit AML population. Outcomes for the elderly remain poor, with less than 20% 5-year overall survival rates. Hence, there is an unmet need to identify treatment strategies to maximize benefit in this age group. Elderly AML is a difficult entity to treat due to both disease and patient-related factors. Treatment of this group has a lot of inter-physician and inter-institutional variability. Several objective criteria to assess biological age, impact of co-morbidities, and fitness have been published, which could be utilized to make management decisions. For old and unfit AML patients, a variety of novel therapeutic agents are currently being investigated. Objective analysis of biological age should include assessment of fitness, frailty, and co-morbidities in elderly AML. Future areas of research include development of an objective risk-based approach and its validation in clinical trials, development of novel therapeutic agents, and improvement in supportive care measures. |
| Databáze: | OpenAIRE |
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