Transendothelial exchange of low-density lipoprotein is unaffected by the presence of severe atherosclerosis
| Autor: | Bo Feldt-Rasmussen, Jonas Peter Eiberg, Kurt Svarre Jensen, Karen Kornerup, Børge G. Nordestgaard, Trine Krogsgaard Jensen, Jan Skov Jensen |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Arteriosclerosis Physiology Vascular permeability Coronary Artery Disease Capillary Permeability chemistry.chemical_compound Physiology (medical) Internal medicine Diabetes mellitus Diabetes Mellitus Humans Medicine Coronary atherosclerosis business.industry Vascular disease Albumin Middle Aged medicine.disease Peripheral Lipoproteins LDL Endocrinology chemistry Case-Control Studies Low-density lipoprotein Female Endothelium Vascular Cardiology and Cardiovascular Medicine business Lipoprotein |
| Zdroj: | Cardiovascular Research. 64:337-345 |
| ISSN: | 0008-6363 |
| Popis: | Objective : We tested the hypothesis that transendothelial exchange of low-density lipoprotein (LDL) is influenced by the presence of severe atherosclerosis; we previously found this exchange elevated in diabetes patients. Methods : By an in vivo isotope method, we compared transendothelial LDL exchange in 24 patients with angiographically verified coronary atherosclerosis, 11 patients with angiographically verified peripheral atherosclerosis, 60 patients with diabetes, and in 42 controls. Autologous 131-iodinated LDL (131I-LDL) and 125-iodinated albumin (125I-albumin) were injected intravenously (i.v.), and the 1-h fractional escape rates (FERLDL and FERalb) were taken as indices of transendothelial exchange. Results : Patients with coronary or peripheral atherosclerosis had FERLDL similar to that of controls [4.3 (3.5–5.1) and 3.2 (2.3–4.1) versus 4.2 (3.7–4.7)%/h; P >0.05], even after adjustment for LDL distribution volume (DVLDL). In contrast, diabetes patients had significantly higher FERLDL than controls [5.2 (4.6–5.7) versus 4.2 (3.7–4.7)%/h; P |
| Databáze: | OpenAIRE |
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