Antagonism of neuromuscular blockade but not muscle relaxation affects depth of anaesthesia
| Autor: | F.C. Vasella, Philippe Frascarolo, Donat R. Spahn, Lennart Magnusson |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Adult Aged Anesthetics Combined/pharmacology Anesthetics Intravenous/*pharmacology Atracurium/pharmacology Blood Pressure/drug effects Cholinesterase Inhibitors/*pharmacology Double-Blind Method Drug Interactions Electroencephalography/drug effects Evoked Potentials Auditory/*drug effects Female Heart Rate/drug effects Humans Male Middle Aged Monitoring Intraoperative/methods Muscle Relaxation/*drug effects Neostigmine/pharmacology *Neuromuscular Blockade Neuromuscular Nondepolarizing Agents/pharmacology Piperidines/pharmacology Propofol/pharmacology Prospective Studies Muscle Relaxation Remifentanil Blood Pressure Double-Blind Method Piperidines Heart Rate Monitoring Intraoperative medicine Humans Drug Interactions General anaesthesia Glycopyrronium bromide Prospective Studies Propofol Aged business.industry Electroencephalography Middle Aged Neuromuscular monitoring Anesthetics Combined Neostigmine Anesthesiology and Pain Medicine Muscle relaxation Bispectral index Anesthesia Atracurium Evoked Potentials Auditory Neuromuscular Blockade Female Cholinesterase Inhibitors business Anesthetics Intravenous Neuromuscular Nondepolarizing Agents medicine.drug |
| Zdroj: | British Journal of Anaesthesia, vol. 94, no. 6, pp. 742-7 |
| Popis: | BACKGROUND: Conflicting effects of neuromuscular blocking drugs and anticholinesterases on depth of anaesthesia have been reported. Therefore we evaluated the effect of atracurium and neostigmine on bispectral index (BIS) and middle-latency auditory evoked potentials (AAI). METHODS: We studied 40 patients (ASA I-II) aged 18-69 yr. General anaesthesia consisted of propofol and remifentanil by target-controlled infusion and neuromuscular function was monitored by electromyography. When BIS reached stable values, patients were randomly assigned to one of two groups. Group 1 received atracurium 0.4 mg kg(-1) and, 5 min later, the same volume of NaCl 0.9%; group 2 received saline first and then atracurium. When the first twitch of a train of four reached 10% of control intensity, patients were again randomized: one group (N) received neostigmine 0.04 mg kg(-1) and glycopyrrolate 0.01 mg kg(-1), and the control group (G) received only glycopyrrolate. RESULTS: Injection of atracurium or NaCl 0.9% had no effect on BIS or AAI. After neostigmine-glycopyrrolate, BIS and AAI increased significantly (mean maximal change of BIS 7.1 [SD 7.5], P |
| Databáze: | OpenAIRE |
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