Prevalence and predictors of malignancies in a polycentric cohort of HIV patients from Italy
| Autor: | M. Tontodonati, Marcello Mazzetti, Giustino Parruti, Chiara Gabrielli, Daniela Francisci, Elena Mazzotta, Jacopo Vecchiet, Francesco Barchiesi, Katia Falasca, Giovanni Cenderello, Susanna Mazzocato |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
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education.field_of_study medicine.medical_specialty Pathology business.industry Population Public Health Environmental and Occupational Health Malignancy medicine.disease Logistic regression Lymphoma Infectious Diseases Acquired immunodeficiency syndrome (AIDS) Internal medicine Cohort medicine Poster Sessions – Abstract P120 Sarcoma business education |
| Zdroj: | Journal of the International AIDS Society |
| Popis: | Introduction : HIV infected patients have a higher risk of developing cancer than the general population. Kaposi's sarcoma, non-Hodgkin's lymphoma, primary CNS lymphoma and invasive cervical cancers are considered as AIDS defining [1]. An increased incidence in recent years has been reported also for other malignancies after the introduction of cART [2,3]. Materials and Methods : We performed a retrospective multicentric evaluation of all HIV infected patients with both AIDS and non-AIDS defining neoplasms at six Infectious Disease Units spread throughout Italy since 1991 through 2013. Cases were compared with equal number of controls without neoplasia followed at the same institutions, matched for length of HIV infection. Results : Since 1991, 339 consecutive cases of malignancy were collected from the six convening centres, including approximately an equal proportion of AIDS (51.2%) and non-AIDS defining tumours. Mean prevalence of tumours among centres was 8.3% (r. 6.1% – 9.6%). Mean age at tumour diagnosis was significantly lower than in controls (42.6±11.0 vs 46.8±10.6 years, respectively, p |
| Databáze: | OpenAIRE |
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