The Determinants of Directionality in Transcriptional Initiation
| Autor: | Dia N. Bagchi, Vishwanath R. Iyer |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Transcriptional Activation
0301 basic medicine Genetics Transcription Genetic biology RNA RNA polymerase II Enhancer RNAs Computational biology Noncoding DNA Article Chromatin 03 medical and health sciences Enhancer Elements Genetic 030104 developmental biology Transcription (biology) biology.protein Humans RNA Polymerase II Promoter Regions Genetic Enhancer Gene |
| Zdroj: | Trends in Genetics. 32:322-333 |
| ISSN: | 0168-9525 |
| DOI: | 10.1016/j.tig.2016.03.005 |
| Popis: | A new paradigm has emerged in recent years characterizing transcription initiation as a bidirectional process encompassing a larger proportion of the genome than previously thought. Past concepts of coding genes thinly scattered among a vast background of transcriptionally inert noncoding DNA have been abandoned. A richer picture has taken shape, integrating transcription of coding genes, enhancer RNAs (eRNAs), and various other noncoding transcriptional events. In this review we give an overview of recent studies detailing the mechanisms of RNA polymerase II (RNA Pol II)-based transcriptional initiation and discuss the ways in which transcriptional direction is established as well as its functional implications. |
| Databáze: | OpenAIRE |
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