Dexamethasone pharmacokinetics in the inner ear: comparison of route of administration and use of facilitating agents
| Autor: | Elizabeth Huang, Ran Y. Rubinstein, Michael Gatz, Soly Baredes, Jed A. Kwartler, Sujana S. Chandrasekhar, Patricia E. Connelly |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Time Factors Tympanic Membrane medicine.medical_treatment Administration Topical Guinea Pigs Radioimmunoassay Perilymph Dexamethasone Steroid 03 medical and health sciences Route of administration chemistry.chemical_compound Random Allocation 0302 clinical medicine Pharmacokinetics Hyaluronic acid otorhinolaryngologic diseases medicine Animals Inner ear Dimethyl Sulfoxide Hyaluronic Acid 030223 otorhinolaryngology Glucocorticoids business.industry medicine.anatomical_structure Otorhinolaryngology chemistry 030220 oncology & carcinogenesis Anesthesia Ear Inner Injections Intravenous Surgery Female sense organs business Histamine medicine.drug |
| Zdroj: | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 122(4) |
| ISSN: | 0194-5998 |
| Popis: | There is growing otologic interest in treating inner ear disorders, such as sudden sensorineural hearing loss and acute or unremitting Meniere’s disease, with intratympanic dexamethasone (IT-DEX). Although anecdotally reported, there are no scientific clinical papers and few prior laboratory research publications on the subject. This study compares perilymph dexamethasone concentrations after systemic and intratympanic administration and assesses the role of 3 potential transport facilitators of IT-DEX into perilymph. Forty guinea pigs (79 ears) were randomly separated into 5 groups. Dexamethasone levels were measured by radioimmunoassay. IT-DEX resulted in higher perilymph steroid levels than intravenous dexamethasone (P < 0.05). Histamine facilitator resulted in significantly higher perilymph steroid levels than IT-DEX alone (P < 0.05). Neither hyaluronic acid nor dimethylsulfoxide was a potent facilitator. This study demonstrates that IT-DEX administration results in superior perilymph levels within 1 hour of administration and does not result in systemic absorption. Histamine is a potent facilitating agent. The clinical implications are considerable. (Otolaryngol Head Neck Surg 2000;122:521-8.) |
| Databáze: | OpenAIRE |
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