Clinical impact of the subclonal architecture and mutational complexity in chronic lymphocytic leukemia
| Autor: | M. J. Terol, Alfons Navarro, M. González, M. Pinyol, Itziar Salaverria, M Aymerich, Sílvia Beà, Armando López-Guillermo, Neus Villamor, Elias Campo, Miguel Alcoceba, Anna Enjuanes, David Martín-García, Dolors Colomer, Pedro Jares, Julio Delgado, Angel Ramirez Payer, Ferran Nadeu, María Rozman, Enrique Colado, Carlos López-Otín, Belen Navarro, Xose S. Puente, Tycho Baumann, Helena Suárez-Cisneros, Guillem Clot |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Cancer Research DNA Copy Number Variations Chronic lymphocytic leukemia Clone (cell biology) Biology medicine.disease_cause Somatic evolution in cancer Genome Clonal Evolution 03 medical and health sciences Young Adult 0302 clinical medicine medicine Biomarkers Tumor Humans Gene Aged Neoplasm Staging Proportional Hazards Models Genetics Aged 80 and over Mutation Hematology Middle Aged medicine.disease Prognosis Leukemia Lymphocytic Chronic B-Cell Leukemia Oncology 030220 oncology & carcinogenesis Disease Progression Original Article Female IGHV@ 030215 immunology Follow-Up Studies Signal Transduction |
| Zdroj: | LEUKEMIA r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA instname Leukemia WOS:000404127001016 RUO. Repositorio Institucional de la Universidad de Oviedo |
| ISSN: | 0887-6924 |
| Popis: | This study was supported by the Instituto de Salud Carlos III (ISCIII) PMP15/00007; Ministerio de Economía y Competitividad (MINECO) SAF2015-64885-R; Generalitat de Catalunya AGAUR 2014-SGR-795; and Gilead Spain (GLD15/00288). ECa is an Academia Researcher of the 'Institució Catalana de Recerca i Estudis Avançats' (ICREA) of the Generalitat de Catalunya. FN is supported by a pre-doctoral fellowship of the MINECO (BES-2016-076372). We are indebted to the Genomics core facility of the Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). We are grateful to N Villahoz and MC Muro for their excellent work in the coordination of the CLL Spanish Consortium, and also thank C Capdevila, S Guijarro, L Pla and M Sánchez for their excellent technical assistance. We are also very grateful to all patients with CLL who have participated in this study. Nadeu, F., Clot, G., Delgado, J., Martín-García, D., Baumann, T., Salaverria, I., Beà, S., Pinyol, M., Jares, P., Navarro, A., Suárez-Cisneros, H., Aymerich, M., Rozman, M., Villamor, N., Colomer, D., González, M., Alcoceba, M., Terol, M.J., Navarro, B., Colado, E., Payer, Á., Puente, X.S., López-Otín, C., López-Guillermo, A., Enjuanes, A., Campo, E. |
| Databáze: | OpenAIRE |
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