Melatonin reduces radiation damage in inner ear
| Autor: | Yuling Luo, Yong Liang, Molu Ban, Wei Zhang, Yixin Yuan, Jin-Hao Peng, Ting Chen, Qi Li, Chen Yang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Hearing loss Health Toxicology and Mutagenesis medicine.medical_treatment Intraperitoneal injection Otoacoustic Emissions Spontaneous melatonin Signal-To-Noise Ratio Melatonin 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Internal medicine medicine otorhinolaryngologic diseases Regular Paper Evoked Potentials Auditory Brain Stem Animals Radiology Nuclear Medicine and imaging Inner ear RNA Messenger Prestin Radiation Injuries radiotherapy 030304 developmental biology 0303 health sciences cochlear damage Mice Inbred BALB C Radiation biology prestin mRNA business.industry Molecular Motor Proteins Auditory Threshold Radiation therapy Auditory brainstem response medicine.anatomical_structure Endocrinology Gene Expression Regulation 030220 oncology & carcinogenesis Ear Inner biology.protein AcademicSubjects/SCI00960 sense organs AcademicSubjects/MED00870 medicine.symptom business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Journal of Radiation Research |
| ISSN: | 1349-9157 0449-3060 |
| Popis: | The purpose of this study was to use a murine model to determine if melatonin can protect the inner ear from radiation-induced damage. A total of 81 4-week-old Balb/c mice were randomly divided into five groups: control group; 50 mg/kg melatonin group; 5 mg/kg melatonin+radiotherapy group; 50 mg/kg melatonin+radiotherapy group; radiotherapy group. The radiotherapy groups received 16 Gy irradiation and melatonin was administered by intraperitoneal injection 30 min before radiotherapy. On days 3 and 7 after irradiation the function of outer hair cells was determined by auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAEs) testing, pathological changes of inner ear cells were observed by light microscopy, and the expression of prestin mRNA was determined. ABR thresholds were increased and wave I latencies were extended after radiotherapy; however, the increases were lower in the groups that received melatonin (P |
| Databáze: | OpenAIRE |
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